Thromboembolic Events Associated with Thalidomide and Multimodality Therapy for Soft Tissue Sarcomas: Results of RTOG 0330

Table 3

Thromboembolic adverse events in 6 patients in cohort A of RTOG 0330.

Tumor site	Adverse event (AE)	AE grade	Timing	Comment
LE	Catheter-associated UE DVT	3	preop	prior to 3rd; cycle MAID
Hip	Bilateral PE	4	preop	1st cycle MAID; (no THAL)
LE	LE DVT	3	postop	4 weeks postop; (ipsilateral)
LE	LE DVT	3	preop	presurgery MRI; (ipsilateral)
LE	LE DVT	3	postop	1 week postop; (ipsilateral)
LE	Bilateral PE	4	preop	2nd cycle MAID

LE: lower extremity; DVT: deep venous thrombosis; PE: pulmonary emboli; preop: preoperative; postop: postoperative; MAID: Mesna/Adriamycin/Ifosphamide/Dacarbazine; THAL: thalidomide; MRI: magnetic resonance imaging; UE: upper extremity.