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Sarcoma
Volume 2012 (2012), Article ID 780129, 8 pages
http://dx.doi.org/10.1155/2012/780129
Review Article

Assessment of Minimal Residual Disease in Ewing Sarcoma

1Division of Pediatric Oncology, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
2Division of Human Genetics, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA
3Division of Bone Marrow Transplantation, Cincinnati Children’s Hospital Medical Center, University of Cincinnati College of Medicine, 3333 Burnet Avenue, Cincinnati, OH 45229, USA

Received 15 August 2011; Accepted 27 October 2011

Academic Editor: R. Pollock

Copyright © 2012 Lars M. Wagner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. C. Chan, W. W. Sutow, R. D. Lindberg et al., “Management and results of localized Ewing's sarcoma,” Cancer, vol. 43, no. 3, pp. 1001–1006, 1979. View at Google Scholar · View at Scopus
  2. G. Schleiermacher, M. Peter, O. Oberlin et al., “Increased risk of systemic relapses associated with bone marrow micrometastasis and circulating tumor cells in localized Ewing tumor,” Journal of Clinical Oncology, vol. 21, no. 1, pp. 85–91, 2003. View at Google Scholar · View at Scopus
  3. B. Thomson, D. Hawkins, J. Felgenhauer, and J. P. Radich, “RT-PCR evaluation of peripheral blood, bone marrow and peripheral blood stem cells in children and adolescents undergoing VACIME chemotherapy for Ewing's sarcoma and alveolar rhabdomyosarcoma,” Bone Marrow Transplantation, vol. 24, no. 5, pp. 527–533, 1999. View at Google Scholar · View at Scopus
  4. U. H. Athale, S. A. Shurtleff, J. J. Jenkins et al., “Use of reverse transcriptase polymerase chain reaction for diagnosis and staging of alveolar rhabdomyosarcoma, Ewing sarcoma family of tumors, and dsm,oplastic small round cell tumors,” Journal of Pediatric Hematology/Oncology, vol. 23, no. 2, pp. 99–104, 2001. View at Google Scholar
  5. S. Avigad, I. J. Cohen, J. Zilberstein et al., “The predictive potential of molecular detection in the nonmetastatic Ewing family of tumors,” Cancer, vol. 100, no. 5, pp. 1053–1058, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. E. de Alava, M. D. Lozano, A. Patino et al., “Ewing family tumors: potential prognosticvalue of reverse- transcriptase polymerase chain reaction detection of minimal residual disease in peripheral blood samples,” Diagnostic Molecular Pathology, vol. 7, no. 3, pp. 152–157, 1998. View at Publisher · View at Google Scholar
  7. M. J. Absalon, M. B. McCarville, T. Liu, V. M. Santana, N. C. Daw, and F. Navid, “Pulmonary nodules discovered during the initial evaluation of pediatric patients with bone and soft-tissue sarcoma,” Pediatric Blood and Cancer, vol. 50, no. 6, pp. 1147–1153, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  8. F. G. Barr and W. H. Meyer, “Role of fusion subtype in Ewing sarcoma,” Journal of clinical oncology, vol. 28, no. 12, pp. 1973–1974, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. M. Peter, H. Magdelenat, J. Michon et al., “Sensitive detection of occult Ewing's cells by the reverse transcriptase-polymerase chain reaction,” British Journal of Cancer, vol. 72, no. 1, pp. 96–100, 1995. View at Google Scholar · View at Scopus
  10. D. Sumerauer, A. Vícha, H. Kucerova et al., “Detection of minimal bone marrow infiltration in patients with localized and metastatic Ewing sarcoma using RT-PCR,” Folia Biologica, vol. 47, no. 6, pp. 206–210, 2001. View at Google Scholar
  11. C. Fagnou, J. Michon, M. Peter et al., “Presence of tumor cells in bone marrow but not in blood is associated with adverse prognosis in patients with Ewing's tumor. Societe Francaise d'Oncologie Pediatrique,” Journal of Clinical Oncology, vol. 16, no. 5, pp. 1707–1711, 1998. View at Google Scholar
  12. D. C. West, H. E. Grier, M. M. Swallow, G. D. Demetri, L. Granowetter, and J. Sklar, “Detection of circulating tumor cells in patients with Ewing's sarcoma and peripheral primitive neuroectodermal tumor,” Journal of Clinical Oncology, vol. 15, no. 2, pp. 583–588, 1997. View at Google Scholar · View at Scopus
  13. C. Pfleiderer, A. Zoubek, B. Gruber et al., “Detection of tumour cells in peripheral blood and bone marrow from Ewing tumour patients by RT-PCR,” International Journal of Cancer, vol. 64, no. 2, pp. 135–139, 1995. View at Google Scholar · View at Scopus
  14. A. Zoubek, R. Ladenstein, R. Windhager et al., “Predictive potential of testing for bone marrow involvement in Ewing tumor patients by RT-PCR: a preliminary evaluation,” International Journal of Cancer, vol. 79, no. 1, pp. 56–60, 1998. View at Publisher · View at Google Scholar · View at Scopus
  15. M. E. Merino, F. Navid, B. L. Christensen et al., “Immunomagnetic purging of Ewing's sarcoma from blood and bone marrow: quantitation by real-time polymerase chain reaction,” Journal of Clinical Oncology, vol. 19, no. 16, pp. 3649–3659, 2001. View at Google Scholar · View at Scopus
  16. I. Yaniv, I. J. Cohen, J. Stein et al., “Tumor cells are present in stem cell harvests of Ewing's sarcoma patients and their persistence following transplantation is associated with relapse,” Pediatric Blood and Cancer, vol. 42, no. 5, pp. 404–409, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. R. S. Bridge, V. Rajaram, L. P. Dehner, J. D. Pfeifer, and A. Perry, “Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors,” Modern Pathology, vol. 19, no. 1, pp. 1–8, 2006. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  18. I. Y. Cheung, Y. Feng, K. Danis et al., “Novel markers of subclinical disease for Ewing family tumors from gene expression profiling,” Clinical Cancer Research, vol. 13, no. 23, pp. 6978–6983, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  19. I. M. Ambros, P. F. Ambros, S. Strehl, H. Kovar, H. Gadner, and M. Salzer-Kuntschik, “MIC2 is a specific marker for Ewing's sarcoma and peripheral primitive neuroectodermal tumors: evidence for a common histogenesis of Ewing's sarcoma and peripheral primitive neuroectodermal tumors from MIC2 expression and specific chromosome aberration,” Cancer, vol. 67, no. 7, pp. 1886–1893, 1991. View at Google Scholar · View at Scopus
  20. S. G. Dubois, C. L. Epling, J. Teague, K. K. Matthay, and E. Sinclair, “Flow cytometric detection of Ewing sarcoma cells in peripheral blood and bone marrow,” Pediatric Blood and Cancer, vol. 54, no. 1, pp. 13–18, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  21. L. Yang, J. C. Lang, P. Balasubramanian et al., “Optimization of an enrichment process for circulating tumor cells from the blood of head and neck cancer patients through depletion of normal cells,” Biotechnology and Bioengineering, vol. 102, no. 2, pp. 521–534, 2009. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  22. S. Ash, D. Luria, I. J. Cohen et al., “Excellent prognosis in a subset of patients with Ewing sarcoma identified at diagnosis by CD56 using flow cytometry,” Clinical Cancer Research, vol. 17, no. 9, pp. 2900–2907, 2011. View at Publisher · View at Google Scholar · View at PubMed
  23. L. J. Gardner, J. M. Polski, R. Fallon, and C. H. Dunphy, “Identification of CD56 and CD57 by flow cytometry in Ewing's sarcoma or primitive neuroactodermal tumor,” Virchows Archiv, vol. 433, no. 1, pp. 35–40, 1998. View at Publisher · View at Google Scholar · View at Scopus
  24. M. J. Borowitz, M. Devidas, S. P. Hunger et al., “Clinical significance of minimal residual disease in childhood acute lymphoblastic leukemia and its relationship to other prognostic factors: a Children's Oncology Group study,” Blood, vol. 111, no. 12, pp. 5477–5485, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  25. Y. J. Kim, D. W. Kim, S. Lee et al., “Comprehensive comparison of FISH, RT-PCR, and RQ-PCR for monitoring the BCR-ABL gene after hematopoietic stem cell transplantation in CML,” European Journal of Haematology, vol. 68, no. 5, pp. 272–280, 2002. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Helgestad, S. Rosthoj, P. Johansen, K. Varming, and E. Ostergaard, “Bone marrow aspiration technique may have an impact on therapy stratification in children with acute lymphoblastic leukaemia,” Pediatric Blood and Cancer, vol. 57, no. 2, pp. 224–226, 2011. View at Publisher · View at Google Scholar · View at PubMed
  27. W. J. Allard, J. Matera, M. C. Miller et al., “Tumor cells circulate in the peripheral blood of all major carcinomas but not in healthy subjects or patients with nonmalignant diseases,” Clinical Cancer Research, vol. 10, no. 20, pp. 6897–6904, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  28. K. Beiske, P. F. Ambros, S. A. Burchill, I. Y. Cheung, and K. Swerts, “Detecting minimal residual disease in neuroblastoma patients-the present state of the art,” Cancer Letters, vol. 228, no. 1-2, pp. 229–240, 2005. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus