Table of Contents Author Guidelines Submit a Manuscript
Sarcoma
Volume 2012 (2012), Article ID 953602, 10 pages
http://dx.doi.org/10.1155/2012/953602
Clinical Study

Should Aggressive Surgical Local Control Be Attempted in All Patients with Metastatic or Pelvic Ewing's Sarcoma?

1Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, 3471 Fifth Avenue, Suite 1010, Pittsburgh, PA 15213, USA
2Division of Musculoskeletal Oncology, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, UPMC Shadyside Medical Building, 5200 Centre Avenue, Suite 415, Pittsburgh, PA 15232, USA
3Division of Musculoskeletal Oncology and Adult Reconstruction, Department of Orthopaedic Surgery, University of Pittsburgh Medical Center, UPMC Shadyside Medical Building, 5200 Centre Avenue, Suite 415, Pittsburgh, PA 15232, USA
4Division of Musculoskeletal Oncology, Departments of Orthopaedic Surgery and Surgery, UPCI Sarcoma Service, University of Pittsburgh Medical Center, UPMC Shadyside Medical Building, 5200 Centre Avenue, Suite 415, Pittsburgh, PA 15232, USA

Received 15 August 2011; Revised 23 October 2011; Accepted 18 November 2011

Academic Editor: Ajay Puri

Copyright © 2012 Steven W. Thorpe et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Sluga, R. Windhager, S. Lang et al., “The role of surgery and resection margins in the treatment of Ewing's sarcoma,” Clinical Orthopaedics and Related Research, no. 392, pp. 394–399, 2001. View at Google Scholar · View at Scopus
  2. C. Rodriguez-Galindo, S. L. Spunt, and A. S. Pappo, “Treatment of ewing sarcoma family of tumors: current status and outlook for the future,” Medical and Pediatric Oncology, vol. 40, no. 5, pp. 276–287, 2003. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  3. P. Rosito, A. F. Mancini, R. Rondelli et al., “Italian cooperative study for the treatment of children and young adults with localized ewing sarcoma of bone: a preliminary report of 6 years of experience,” Cancer, vol. 86, no. 3, pp. 421–428, 1999. View at Publisher · View at Google Scholar · View at Scopus
  4. O. Delattre, J. Zucman, T. Melot et al., “The Ewing family of tumors—a subgroup of small-round-cell tumors defined by specific chimeric transcripts,” New England Journal of Medicine, vol. 331, no. 5, pp. 294–299, 1994. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  5. J. A. Ludwig, “Ewing sarcoma: historical perspectives, current state-of-the-art, and opportunities for targeted therapy in the future,” Current Opinion in Oncology, vol. 20, no. 4, pp. 412–418, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  6. C. E. Herzog, “Overview of sarcomas in the adolescent and young adult population,” Journal of Pediatric Hematology/Oncology, vol. 27, no. 4, pp. 215–218, 2005. View at Publisher · View at Google Scholar · View at Scopus
  7. A. V. Maheshwari and E. Y. Cheng, “Ewing sarcoma family of tumors,” Journal of the American Academy of Orthopaedic Surgeons, vol. 18, no. 2, pp. 97–107, 2010. View at Google Scholar · View at Scopus
  8. C. Rodríguez-Galindo, F. Navid, T. Liu, C. A. Billups, B. N. Rao, and M. J. Krasin, “Prognostic factors for local and distant control in Ewing sarcoma family of tumors,” Annals of Oncology, vol. 19, no. 4, pp. 814–820, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  9. C. Rodríguez-Galindo, T. Liu, M. J. Krasin et al., “Analysis of prognostic factors in Ewing sarcoma family of tumors,” Cancer, vol. 110, no. 2, pp. 375–384, 2007. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  10. S. Cotterill, S. Ahrens, M. Paulussen et al., “Prognostic factors in Ewing's tumor of bone: analysis of 975 patients from the European Intergroup Cooperative Ewing's Sarcoma Study Group,” Journal of Clinical Oncology, vol. 18, no. 17, pp. 3108–3114, 2000. View at Google Scholar · View at Scopus
  11. H. Jürgens, U. Exner, H. Gadner et al., “Multidisciplinary treatment of primary Ewing's sarcoma of bone: a 6-year experience of a European Cooperative trial,” Cancer, vol. 61, no. 1, pp. 23–32, 1988. View at Google Scholar · View at Scopus
  12. J. Lee, B. H. Hoang, A. Ziogas, and J. A. Zell, “Analysis of prognostic factors in Ewing sarcoma using a population-based cancer registry,” Cancer, vol. 116, no. 8, pp. 1964–1973, 2010. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  13. G. Bacci, S. Ferrari, F. Bertoni et al., “Prognostic factors in nonmetastatic Ewing's sarcoma of bone treated with adjuvant chemotherapy: analysis of 359 patients at the Istituto Ortopedico Rizzoli,” Journal of Clinical Oncology, vol. 18, no. 1, pp. 4–11, 2000. View at Google Scholar · View at Scopus
  14. A. Craft, S. Cotterill, A. Malcolm et al., “Ifosfamide-containing chemotherapy in Ewing's sarcoma: the second United Kingdom Children's Cancer Study Group and the Medical Research Council Ewing's Tumor Study,” Journal of Clinical Oncology, vol. 16, no. 11, pp. 3628–3633, 1998. View at Google Scholar · View at Scopus
  15. N. Esiashvili, M. Goodman, and R. Marcus, “Changes in incidence and survival of ewing sarcoma patients over the past 3 decades,” Journal of Pediatric Hematology/Oncology, vol. 30, no. 6, pp. 425–430, 2008. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  16. J. S. Miser, M. D. Krailo, N. J. Tarbell et al., “Treatment of metastatic Ewing's sarcoma or primitive neuroectodermal tumor of bone: evaluation of combination ifosfamide and etoposide—a children's cancer group and pediatric oncology group study,” Journal of Clinical Oncology, vol. 22, no. 14, pp. 2873–2876, 2004. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  17. G. Bacci, A. Toni, M. Avella et al., “Long-term results in 144 localized Ewing's sarcoma patients treated with combined therapy,” Cancer, vol. 63, no. 8, pp. 1477–1486, 1989. View at Google Scholar · View at Scopus
  18. R. Capanna, A. Toni, A. Sudanese, D. McDonald, G. Bacci, and M. Campanacci, “Ewing's sarcoma of the pelvis,” International Orthopaedics, vol. 14, no. 1, pp. 57–61, 1990. View at Google Scholar · View at Scopus
  19. W. K. Li, J. M. Lane, and G. Rosen, “Pelvic Ewing's sarcoma. Advances in treatment,” Journal of Bone and Joint Surgery, vol. 65, no. 6, pp. 738–747, 1983. View at Google Scholar · View at Scopus
  20. F. J. Frassica, A. D. Frassica, D. J. Pritchard, P. J. Schomberg, L. E. Wold, and F. H. Sim, “Ewing sarcoma of the pelvis. Clinicopathological features and treatment,” Journal of Bone and Joint Surgery, vol. 75, no. 10, pp. 1457–1465, 1993. View at Google Scholar · View at Scopus
  21. R. Ahmad, B. R. Mayol, M. Davis, and B. T. Rougraff, “Extraskeletal Ewing's sarcoma,” Cancer, vol. 85, no. 3, pp. 725–731, 1999. View at Publisher · View at Google Scholar · View at Scopus
  22. E. O. Burgert Jr., M. E. Nesbit, L. A. Garnsey et al., “Multimodal therapy for the management of nonpelvic, localized Ewing's sarcoma of bone: intergroup study IESS-II,” Journal of Clinical Oncology, vol. 8, no. 9, pp. 1514–1524, 1990. View at Google Scholar · View at Scopus
  23. A. G. Shankar, C. R. Pinkerton, A. Atra et al., “Local therapy and other factors influencing site of relapse in patients with localised Ewing's sarcoma,” European Journal of Cancer, vol. 35, no. 12, pp. 1698–1704, 1999. View at Publisher · View at Google Scholar · View at Scopus
  24. R. S. Yang, J. J. Eckardt, F. R. Eilber et al., “Surgical indications for Ewing's sarcoma of the pelvis,” Cancer, vol. 76, no. 8, pp. 1388–1397, 1995. View at Publisher · View at Google Scholar · View at Scopus
  25. J. S. Wunder, G. Paulian, A. G. Huvos, G. Heller, P. A. Meyers, and J. H. Healey, “The histological response to chemotherapy as a predictor of the oncological outcome of operative treatment of Ewing Sarcoma,” Journal of Bone and Joint Surgery, vol. 80, no. 7, pp. 1020–1033, 1998. View at Google Scholar · View at Scopus
  26. F. A. Hayes, E. I. Thompson, W. H. Meyer et al., “Therapy for localized Ewing's sarcoma of bone,” Journal of Clinical Oncology, vol. 7, no. 2, pp. 208–213, 1989. View at Google Scholar · View at Scopus
  27. A. Pradhan, R. J. Grimer, D. Spooner et al., “Oncological outcomes of patients with Ewing's sarcoma: is there a difference between skeletal and extraskeletal ewing's sarcoma?” Journal of Bone and Joint Surgery, vol. 93, no. 4, pp. 531–536, 2011. View at Publisher · View at Google Scholar · View at PubMed
  28. C. Rodriguez-Galindo, C. A. Billups, L. E. Kun et al., “Survival after recurrence of ewing tumors,” Cancer, vol. 94, no. 2, pp. 561–569, 2002. View at Publisher · View at Google Scholar · View at PubMed · View at Scopus
  29. N. P. Rud, H. M. Reiman, D. J. Pritchard, F. J. Frassica, and W. A. Smithson, “Extraosseous Ewing's sarcoma,” Cancer, vol. 64, no. 7, pp. 1548–1553, 1989. View at Google Scholar · View at Scopus
  30. M. E. Nesbit, E. A. Gehan, E. O. Burgert et al., “Multimodal therapy for the management of primary, nonmetastatic Ewing's Sarcoma of bone: a long-term follow-up of the first intergroup study,” Journal of Clinical Oncology, vol. 8, no. 10, pp. 1664–1674, 1990. View at Google Scholar · View at Scopus
  31. P. Picci, T. Böhling, S. Bacci et al., “Chemotherapy-induced tumor necrosis as a prognostic factor in localized Ewing's sarcoma of the extremities,” Journal of Clinical Oncology, vol. 15, no. 4, pp. 1553–1559, 1997. View at Google Scholar · View at Scopus
  32. G. Bacci, P. Picci, and S. Gitelis, “The treatment of localized Ewing's sarcoma: the experience at the Istituto Ortopedico Rizzoli in 163 cases treated with and without adjuvant chemotherapy,” Cancer, vol. 49, no. 8, pp. 1561–1570, 1982. View at Google Scholar · View at Scopus
  33. M. A. Applebaum, J. Worch, K. K. Matthay et al., “Clinical features and outcomes in patients with extraskeletal Ewing sarcoma,” Cancer, vol. 117, no. 13, pp. 3027–3032, 2011. View at Publisher · View at Google Scholar