Can Bone Tissue Engineering Contribute to Therapy Concepts after Resection of Musculoskeletal Sarcoma?
Figure 5
Schematic illustration of the scaffold manufacturing process. A 3D computer-aided designed (CAD) model of the patient’s pelvis is fabricated according to data obtained by high-resolution CT ((a), (b)). Using this prototype, the surgeon indicates the osteotomy planes needed to achieve tumour-free resection margins, after which the CAD model is virtually resected ((c), (d)). A scaffold model is then derived by mirroring the healthy side of the pelvis and adjusting the size to fit into the defect ((e), (f)). The scaffold can be armed with flanges or an intramedullary peg to enhance its primary stability ((g), (h)) and exhibits a porous internal architecture to allow for tissue ingrowth and regeneration (i).
