Figure 1: Mean excess over the highest single agent (EOHSA) versus value for tested drug combinations in U2-OS osteosarcoma cells. EOHSA was calculated from cell viability assay dose response data for drug combinations and individual drugs for each combination. Results from combinations with potentially more significant synergy will show up in the upper right. Drug combinations are listed in the legend in order of the mean EOHSA value, with higher values appearing first. Symbol size represents the relative number of experiments included in the mean EOHSA value.