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Volume 2014 (2014), Article ID 450902, 4 pages
Research Article

Validation of the SF-6D Health State Utilities Measure in Lower Extremity Sarcoma

Department of Orthopaedics & Sports Medicine, University of Washington Medical Center, 1959 Pacific Street NE, Box 356500, Seattle, WA 98195, USA

Received 26 December 2013; Accepted 16 February 2014; Published 19 March 2014

Academic Editor: Charles Catton

Copyright © 2014 Kenneth R. Gundle et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Aim. Health state utilities measures are preference-weighted patient-reported outcome (PRO) instruments that facilitate comparative effectiveness research. One such measure, the SF-6D, is generated from the Short Form 36 (SF-36). This report describes a psychometric evaluation of the SF-6D in a cross-sectional population of lower extremity sarcoma patients. Methods. Patients with lower extremity sarcoma from a prospective database who had completed the SF-36 and Toronto Extremity Salvage Score (TESS) were eligible for inclusion. Computed SF-6D health states were given preference weights based on a prior valuation. The primary outcome was correlation between the SF-6D and TESS. Results. In 63 pairs of surveys in a lower extremity sarcoma population, the mean preference-weighted SF-6D score was 0.59 (95% CI 0.4–0.81). The distribution of SF-6D scores approximated a normal curve (skewness = 0.11). There was a positive correlation between the SF-6D and TESS ( , ). Respondents who reported walking aid use had lower SF-6D scores (0.53 versus 0.61, ). Five respondents underwent amputation, with lower SF-6D scores that approached significance (0.48 versus 0.6, ). Conclusions. The SF-6D health state utilities measure demonstrated convergent validity without evidence of ceiling or floor effects. The SF-6D is a health state utilities measure suitable for further research in sarcoma patients.