High Dose Thiotepa in Patients with Relapsed or Refractory Osteosarcomas: Experience of the SFCE Group

Table 3

Univariate analysis.

Factors	Number of patients	Number of deaths	5-year overall survival (%)	𝑃 value; (Log-Rank test)
Initial histological response
Good response	17	13	29	0.82
Poor response	28	20	17
Radiological response
Partial response	12	10	17	0.57
Stable disease or progressive disease	27	20	33
Surgery after thiotepa (TTP)
Yes	31	22	36	0.397
No	14	11	21
Histological response after TTP
Good response	9	2	56	0.17
Poor response	22	18	27
Number of previous relapses
First relapse	26	18	31	0.69
Subsequent relapse	17	13	29
Delay between diagnosis and relapse before TTP
≤2 years	19	16	16	0.01
>2 years	24	15	42