Histopathological Diagnostic Discrepancies in Soft Tissue Tumours Referred to a Specialist Centre: Reassessment in the Era of Ancillary Molecular Diagnosis

Table 3

Summary of cases showing major discrepancy.

Referral diagnosis	Final Diagnosis	𝑛
Benign	Malignant (Including locally aggressive, although non-metastasising neoplasms)
Angiomyxoma	Fibromatosis	1
Nerve sheath tumour	Fibromatosis	1
Granular cell tumour (benign)	Granular cell tumour (malignant)	4; (1 patient)
Haemangiopericytoma	DDL	1
Leiomyoma	Leiomyosarcoma	2
Reactive tissue	Leiomyosarcoma	1
Malignant (Including locally aggressive although non-metastasising neoplasms)	Benign
Fibromatosis	Scar	1
Fibromatosis	Nuchal-type fibroma	1
ALT	Lipoma	2
MPNST	Atypical neurofibroma	1
Leiomyosarcoma	BFH	1
DFSP	BFH	1
Metastatic renal carcinoma	Clear cell BFH	1
Angiosarcoma	Haemangioma	1
GIST	Fibrous tissue only	1
Leiomyosarcoma	Schwannoma	1
IMT	Wegener’s granulomatosis	1
Malignant	Malignant
STUMP	Leiomyosarcoma (grade 2)	2
ESS	Leiomyosarcoma	1
ESS	Osteosarcoma	1
GIST	Spindle cell sarcoma	1
GIST	Spindle RMS	1
Leiomyosarcoma	MPNST	1
LGFMS	Fibromatosis	1
LGFMS	DDL	1
Synovial sarcoma	Malignant neoplasm	1
Benign	Benign
Schwannoma	Benign naevus	1
Mesenchymal	Non-mesenchymal
UPS	Carcinosarcoma	4
Synovial sarcoma	Carcinosarcoma	1
Chondrosarcoma	Carcinosarcoma	1
Leiomyosarcoma	Carcinosarcoma	1
Sarcoma	Seminoma	1
MPNST	Melanoma	2
Non-mesenchymal	Mesenchymal
Carcinoma	Pleomorphic RMS	1
Carcinoma	Spindle cell sarcoma	1
Lymphoma	SFT	1
Non-mesenchymal	Non-mesenchymal
Undifferentiated carcinoma	Prostatic carcinoma	1
Grade	Grade
GIST grade 2/3	GIST 1	2
Leiomyosarcoma 2/3	Leiomyosarcoma 1	2
Leiomyosarcoma 1	Leiomyosarcoma 2	1
Myxofibrosarcoma 2	Myxofibrosarcoma 1	1
WDL	DDL grade 2	1
High grade sarcoma	ESS	1

Abbreviations: ALT atypical lipomatous tumour; BFH benign fibrous histiocytoma; DFSP dermatofibrosarcoma protuberans; DDL dedifferentiated liposarcoma; ESS endometrial stromal sarcoma; GIST gastrointestinal stromal tumour; IMT inflammatory myofibroblastic tumour; LGFMS low grade fibromyxoid sarcoma; MPNST malignant peripheral nerve sheath tumour; RMS rhabdomyosarcoma; SFT solitary fibrous tumour; STUMP smooth muscle tumour of uncertain malignant potential; UPS undifferentiated pleomorphic sarcoma; WDL well differentiated liposarcoma.