Clinical Features and Outcomes Differ between Skeletal and Extraskeletal Osteosarcoma

Table 3

Univariate and multivariate prognostic factors for overall survival in a cohort of patients with localized extraskeletal osteosarcoma.

	Univariate hazard ratio; (95% confidence interval)	Univariate value	Multivariate hazard ratio; (95% confidence interval)	Multivariate value
Tumor size ≥10 cm	2.06; (1.36–3.14)	0.001	2.36; (1.53–3.62)	<0.0001
Axial tumor	2.04; (1.35–3.07)	0.001	2.01; (1.30–3.11)	0.002
Age; 18–32 years; 33–59 years; 60–99 years	Reference; 1.28 (0.53–3.07); 2.26 (0.98–5.20)	0.580; 0.055	Not tested	Not tested
Regional lymph node present	2.33; (1.23–4.41)	0.009	Not tested	Not tested
Male gender	1.27; (0.88–1.85)	0.204	Not tested	Not tested
Year of diagnosis; 1973–1979; 1980–1989; 1990–1999; 2000–2009	1.39 (0.49–3.91); 0.69 (0.34–1.42); 0.99 (0.65–1.51); Reference	0.537; 0.316; 0.964	Not tested	Not tested