Sarcoma / 2015 / Article / Fig 2

Review Article

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Figure 2

Myogenic pathways in the tumorigenesis of RMS. In aberrant neoplastic condition, progenitor cells residing in muscle result in aberrant pathways, which lead to malignant transformation and fail to differentiate, proliferate uncontrollably, and form RMS. Sharp arrows (→) indicate upregulation/activation and blunt arrows (⊥) indicate downregulation/inhibition.