Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Figure 3

Genetic analyses of RMS have pinpointed several common alterations, including inactivation of a master regulator of p53 and Rb pathways, CDKN2A/B, and activation of FGFR4, RAS, and Hedgehog (Hh) signaling. The modifications of these pathways influence oncogenesis and metastatic potential.