Sarcoma / 2015 / Article / Tab 5

Review Article

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 5

In vivo animal models of RMS.

ModelTargetModel originReference
InactivationExpression

DrosophilaPAX-FKHRBipartite Gal4-UAS expression systemGalindo et al., 2006 [49]
PAX7-FOXO1rolsChromosomal deletion, Df(3L)vin5Avirneni-Vadlamudi et al., 2012 [50]

Zebrafishrag2 promoterc-MyckRAS Chen and Langenau, 2011 [51]
MAPK/ERK and AKT/S6K1 PD98059, TPCKTg(hsp70-HRAS)Le et al., 2012 [52]

MouseSufuN-myc, Sfrp1, Ptch2, and cyclin D1SufuLee et al., 2007 [53]
Ink4a/Arf and Trp53Pax3:FKHRPax3Keller et al., 2004 [54]
Wnt/β-catenin signaling pathwayWnt2p53/c-fosSingh et al., 2010 [55]