Rhabdomyosarcoma: Advances in Molecular and Cellular Biology

Table 5

In vivo animal models of RMS.

Model	Target		Model origin	Reference
	Inactivation	Expression
Drosophila		PAX-FKHR	Bipartite Gal4-UAS expression system	Galindo et al., 2006 [49]
	PAX7-FOXO1	rols	Chromosomal deletion, Df(3L)vin5	Avirneni-Vadlamudi et al., 2012 [50]
Zebrafish	rag2 promoter	c-Myc	kRAS	Chen and Langenau, 2011 [51]
	MAPK/ERK and AKT/S6K1	PD98059, TPCK	Tg(hsp70-HRAS)	Le et al., 2012 [52]
Mouse	Sufu	N-myc, Sfrp1, Ptch2, and cyclin D1	Sufu	Lee et al., 2007 [53]
	Ink4a/Arf and Trp53	Pax3:FKHR	Pax3	Keller et al., 2004 [54]
	Wnt/β-catenin signaling pathway	Wnt2	p53/c-fos	Singh et al., 2010 [55]