Genomic, Epigenomic, and Transcriptomic Profiling towards Identifying Omics Features and Specific Biomarkers That Distinguish Uterine Leiomyosarcoma and Leiomyoma at Molecular Levels

Figure 3

Transcriptome analysis for NM, LM, LMS, and LMS-derived cell lines. (a) Hierarchical clustering analysis for the normalized -transformed intensities of the 1,036 differentially expressed genes using Heatmap2. (b) Three-dimensional visualization of PCA for the entire probe set. (c) Candidate expression markers. Of the 45 LMS-specific genes selected, only six, whose intensities in LMS and LMS-derived cell lines are >9, are shown (full genes are shown in Supplementary Material, Table S3). (d) GO analysis for up- and downregulated genes in each of the LM and LMS samples. The top three GO terms of biological process and their values are shown in black when the corresponding Benjamini’s corrected value was <0.05 or are otherwise shown in grey.

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