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Sarcoma
Volume 2015, Article ID 516843, 14 pages
http://dx.doi.org/10.1155/2015/516843
Research Article

Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient

1Department of Oncology, Oslo University Hospital, Norwegian Radium Hospital, 0424 Oslo, Norway
2The Norwegian Cancer Registry, 0304 Oslo, Norway
3Department of Oncology, Haukeland University Hospital, 5020 Bergen, Norway
4Oslo Center for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, 0424 Oslo, Norway
5Department of Orthopedics, Oslo University Hospital, Norwegian Radium Hospital, 0424 Oslo, Norway
6Institute of Clinical Medicine, University of Oslo, 0318 Oslo, Norway

Received 26 September 2014; Accepted 12 January 2015

Academic Editor: Eugenie S. Kleinerman

Copyright © 2015 Kjetil Berner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J. Whelan, B. Seddon, and M. Perisoglu, “Management of osteosarcoma,” Current Treatment Options in Oncology, vol. 7, no. 6, pp. 444–455, 2006. View at Publisher · View at Google Scholar · View at Scopus
  2. N. Jaffe, “Osteosarcoma: review of the past, impact on the future. The American experience,” Cancer Treatment and Research, vol. 152, pp. 239–262, 2009. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Ferrari, E. Palmerini, E. L. Staals et al., “The treatment of nonmetastatic high grade osteosarcoma of the extremity: review of the Italian Rizzoli experience. Impact on the future,” Cancer Treatment and Research, vol. 152, pp. 275–287, 2009. View at Publisher · View at Google Scholar · View at Scopus
  4. S. Bielack, H. Jürgens, G. Jundt et al., “Osteosarcoma: the COSS experience,” Cancer Treatment and Research, vol. 152, pp. 289–308, 2009. View at Publisher · View at Google Scholar · View at Scopus
  5. Ø. S. Bruland, H. Bauer, T. Alvegaard, and S. Smeland, “Treatment of osteosarcoma. The Scandinavian Sarcoma Group experience,” Cancer Treatment and Research, vol. 152, pp. 309–318, 2009. View at Publisher · View at Google Scholar · View at Scopus
  6. S. Bielack, D. Carrle, and P. G. Casali, “Osteosarcoma: ESMO clinical recommendations for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 20, no. 4, pp. iv137–iv139, 2009. View at Publisher · View at Google Scholar · View at Scopus
  7. P. C. Hogendoorn, N. Athanasou, S. Bielack, and et al, “Bone sarcomas: ESMO clinical practice guidelines for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 21, supplement 5, pp. v204–v213, 2010. View at Publisher · View at Google Scholar · View at Scopus
  8. Ø. S. Bruland and A. Pihl, “On the current management of osteosarcoma. A critical evaluation and a proposal for a modified treatment strategy,” European Journal of Cancer, vol. 33, no. 11, pp. 1725–1731, 1997. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Luetke, P. A. Meyers, I. Lewis, and H. Juergens, “Osteosarcoma treatment—where do we stand? A state of the art review,” Cancer Treatment Reviews, vol. 40, no. 4, pp. 523–532, 2014. View at Publisher · View at Google Scholar · View at Scopus
  10. K. Berner, T. B. Johannesen, A. Berner et al., “Time-trends on incidence and survival in a nationwide and unselected cohort of patients with skeletal osteosarcoma,” Acta Oncologica, vol. 54, no. 1, pp. 25–33, 2015. View at Publisher · View at Google Scholar
  11. S. E. Larsson and R. Lorentzon, “The geographic variation of the incidence of malignant primary bone tumors in Sweden,” The Journal of Bone and Joint Surgery—American Volume, vol. 56, no. 3, pp. 592–600, 1974. View at Google Scholar · View at Scopus
  12. S. Harvei and O. Solheim, “The prognosis in osteosarcoma: norwegian national data,” Cancer, vol. 48, no. 8, pp. 1719–1723, 1981. View at Publisher · View at Google Scholar · View at Scopus
  13. C. A. Stiller, S. J. Passmore, M. E. Kroll, P. A. Brownbill, J. C. Wallis, and A. W. Craft, “Patterns of care and survival for patients aged under 40 years with bone sarcoma in Britain, 1980–1994,” British Journal of Cancer, vol. 94, no. 1, pp. 22–29, 2006. View at Publisher · View at Google Scholar · View at Scopus
  14. H. Curry, G. Horne, P. Devane, and H. Tobin, “Osteosarcoma in New Zealand: an outcome study comparing survival rates between 1981–1987 and 1994–1999,” The New Zealand Medical Journal, vol. 119, no. 1242, Article ID U2234, 2006. View at Google Scholar · View at Scopus
  15. M. M. Sampo, M. Tarkkanen, A. H. Kivioja, M. H. Taskinen, R. Sankila, and T. O. Böhling, “Osteosarcoma in Finland from 1971 through 1990: a nationwide study of epidemiology and outcome,” Acta Orthopaedica, vol. 79, no. 6, pp. 861–866, 2008. View at Publisher · View at Google Scholar · View at Scopus
  16. M. Sampo, M. Koivikko, M. Taskinen et al., “Incidence, epidemiology and treatment results of osteosarcoma in Finland—a nationwide population-based study,” Acta Oncologica, vol. 50, no. 8, pp. 1206–1214, 2011. View at Publisher · View at Google Scholar · View at Scopus
  17. J. Whelan, A. McTiernan, N. Cooper et al., “Incidence and survival of malignant bone sarcomas in England 1979–2007,” International Journal of Cancer, vol. 131, no. 4, pp. E508–E517, 2012. View at Publisher · View at Google Scholar · View at Scopus
  18. M. S. Kim, S.-Y. Lee, W. H. Cho et al., “Prognostic effects of doctor-associated diagnostic delays in osteosarcoma,” Archives of Orthopaedic and Trauma Surgery, vol. 129, no. 10, pp. 1421–1425, 2009. View at Publisher · View at Google Scholar · View at Scopus
  19. P. Rustad, P. Felding, L. Franzson et al., “The Nordic Reference Interval Project 2000: recommended reference intervals for 25 common biochemical properties,” Scandinavian Journal of Clinical and Laboratory Investigation, vol. 64, no. 4, pp. 271–283, 2004. View at Publisher · View at Google Scholar · View at Scopus
  20. G. Saeter, T. A. Alvegard, I. Elomaa, A. E. Stenwig, T. Holmstrom, and O. P. Solheim, “Treatment of osteosarcoma of the extremities with the T-10 protocol, with emphasis on the effects of preoperative chemotherapy with single-agent high-dose methotrexate: a Scandinavian Sarcoma Group study,” Journal of Clinical Oncology, vol. 9, no. 10, pp. 1766–1775, 1991. View at Google Scholar · View at Scopus
  21. S. Smeland, C. Müller, T. A. Alvegard et al., “Scandinavian Sarcoma Group Osteosarcoma Study SSG VIII: prognostic factors for outcome and the role of replacement salvage chemotherapy for poor histological responders,” European Journal of Cancer, vol. 39, no. 4, pp. 488–494, 2003. View at Publisher · View at Google Scholar · View at Scopus
  22. S. Ferrari, S. Smeland, M. Mercuri et al., “Neoadjuvant chemotherapy with high-dose ifosfamide, high-dose methotrexate, cisplatin, and doxorubicin for patients with localized osteosarcoma of the extremity: a joint study by the italian and Scandinavian Sarcoma Groups,” Journal of Clinical Oncology, vol. 23, no. 34, pp. 8845–8852, 2005. View at Publisher · View at Google Scholar · View at Scopus
  23. K. Boye, A. B. Del Prever, M. Eriksson et al., “High-dose chemotherapy with stem cell rescue in the primary treatment of metastatic and pelvic osteosarcoma: final results of the ISG/SSG II study,” Pediatric Blood & Cancer, vol. 61, no. 5, pp. 840–845, 2014. View at Publisher · View at Google Scholar
  24. S. Smeland, Ø. S. Bruland, L. Hjorth et al., “Results of the Scandinavian Sarcoma Group XIV protocol for classical osteosarcoma: 63 patients with a minimum follow-up of 4 years,” Acta Orthopaedica, vol. 82, no. 2, pp. 211–216, 2011. View at Publisher · View at Google Scholar · View at Scopus
  25. D. Carrle and S. S. Bielack, “Current strategies of chemotherapy in osteosarcoma,” International Orthopaedics, vol. 30, no. 6, pp. 445–451, 2006. View at Publisher · View at Google Scholar · View at Scopus
  26. N. Marina, S. Bielack, J. Whelan et al., “International collaboration is feasible in trials for rare conditions: the EURAMOS experience,” Cancer Treatment and Research, vol. 152, pp. 339–353, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. EURAMOS, 2014, http://212.219.75.232/euramos/.
  28. S. Bielack, S. Smeland, J. Whelan et al., “MAP plus maintenance pegylated interferon α-2b (MAPIfn) versus MAP alone in patients with resectable high-grade osteosarcoma and good histologic response to preoperative MAP: first results of the EURAMOS-1 ‘good response’ randomization,” Journal of Clinical Oncology, vol. 31, supplement, abstract LBA10504, 2013. View at Google Scholar
  29. EURAMOS-1-Poor-Response-Randomisation1, 2014, http://www.ssg-org.net/wp-content/uploads/2011/03/EURAMOS-1-Poor-Response-Randomisation1.pdf.
  30. R. Schwarz, O. Bruland, A. Cassoni, P. Schomberg, and S. Bielack, “The role of radiotherapy in osteosarcoma,” Cancer Treatment and Research, vol. 152, pp. 147–164, 2009. View at Publisher · View at Google Scholar · View at Scopus
  31. A. Hershey, G. D. Bos, and K. Stevens, “Successful treatment of spinal osteosarcoma with radiation and chemotherapy,” Orthopedics, vol. 19, no. 7, pp. 617–618, 1996. View at Google Scholar · View at Scopus
  32. M. M. Hernberg, A. H. Kivioja, T. O. Böhling, R. J. Janes, and T. A. Wiklund, “Chemoradiotherapy in the treatment of inoperable high-grade osteosarcoma,” Medical Oncology, vol. 28, no. 4, pp. 1475–1480, 2011. View at Publisher · View at Google Scholar · View at Scopus
  33. G. Sæter and Ø. S. Bruland, “High-grade osteosarcoma: the scope beyond the classical patient,” in Towards the Eradication of Osteosarcoma Metastasis—An Odyssey, pp. 21–23, 1998. View at Google Scholar
  34. J. K. Anninga, H. Gelderblom, M. Fiocco et al., “Chemotherapeutic adjuvant treatment for osteosarcoma: where do we stand?” European Journal of Cancer, vol. 47, no. 16, pp. 2431–2445, 2011. View at Publisher · View at Google Scholar · View at Scopus
  35. W. F. Enneking, S. S. Spanier, and M. A. Goodman, “A system for the surgical staging of musculoskeletal sarcoma,” Clinical Orthopaedics and Related Research, vol. 153, pp. 106–120, 1980. View at Google Scholar · View at Scopus
  36. E. L. Kaplan and P. Meier, “Nonparametric estimation from incomplete observations,” Journal of the American Statistical Association, vol. 53, pp. 457–481, 1958. View at Publisher · View at Google Scholar · View at MathSciNet
  37. N. Mantel, “Evaluation of survival data and two new rank order statistics arising in its consideration,” Cancer Chemotherapy Reports, vol. 50, no. 3, pp. 163–170, 1966. View at Google Scholar · View at Scopus
  38. D. R. Cox, “Regression models and life-tables,” Journal of the Royal Statistical Society. Series B. Methodological, vol. 34, pp. 187–220, 1972. View at Google Scholar · View at MathSciNet
  39. P. Brandal, B. Bjerkehagen, Ø. S. Bruland, S. Skjeldal, T. V. Bogsrud, and K. S. Hall, “Synchronous and metachronous skeletal osteosarcomas: the Norwegian Radium Hospital experience,” Acta Oncologica, vol. 48, no. 8, pp. 1165–1172, 2009. View at Publisher · View at Google Scholar · View at Scopus
  40. W. R. Gilks, S. Richardson, and D. J. Spiegelhalter, Markov Chain Monte Carlo in Practice, Interdisciplinary Statistics, Chapman & Hall, London, UK, 1996. View at Publisher · View at Google Scholar · View at MathSciNet
  41. H. Tsuchiya and K. Tomita, “Prognosis of osteosarcoma treated by limb-salvage surgery: the ten-year intergroup study in Japan,” Japanese Journal of Clinical Oncology, vol. 22, no. 5, pp. 347–353, 1992. View at Google Scholar · View at Scopus
  42. S. S. Bielack, B. Kempf-Bielack, G. Delling et al., “Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols,” Journal of Clinical Oncology, vol. 20, no. 3, pp. 776–790, 2002. View at Publisher · View at Google Scholar · View at Scopus
  43. G. Bacci, S. Ferrari, S. Lari et al., “Osteosarcoma of the limb: amputation or limb salvage in patients treated by neoadjuvant chemotherapy,” The Journal of Bone & Joint Surgery—British Volume, vol. 84, no. 1, pp. 88–92, 2002. View at Publisher · View at Google Scholar
  44. G. A. Marulanda, E. R. Henderson, D. A. Johnson, G. D. Letson, and D. Cheong, “Orthopedic surgery options for the treatment of primary osteosarcoma,” Cancer Control, vol. 15, no. 1, pp. 13–20, 2008. View at Google Scholar
  45. S. S. Bielack, B. Wulff, G. Delling et al., “Osteosarcoma of the trunk treated by multimodal therapy: experience of the Cooperative Osteosarcoma study group (COSS),” Medical and Pediatric Oncology, vol. 24, no. 1, pp. 6–12, 1995. View at Publisher · View at Google Scholar · View at Scopus
  46. G. Saeter, O. S. Bruland, G. Folleras, M. Boysen, and J. Hoie, “Extremity and non-extremity high-grade osteosarcoma—the Norwegian Radium Hospital experience during the modern chemotherapy era,” Acta Oncologica, vol. 35, supplement 8, pp. 129–134, 1996. View at Google Scholar · View at Scopus
  47. G. Bacci, A. Longhi, S. Ferrari et al., “Prognostic significance of serum lactate dehydrogenase in osteosarcoma of the extremity: experience at Rizzoli on 1421 patients treated over the last 30 years,” Tumori, vol. 90, no. 5, pp. 478–484, 2004. View at Google Scholar · View at Scopus
  48. M. U. Jawad, M. C. Cheung, J. Clarke, L. G. Koniaris, and S. P. Scully, “Osteosarcoma: improvement in survival limited to high-grade patients only,” Journal of Cancer Research and Clinical Oncology, vol. 137, no. 4, pp. 597–607, 2011. View at Publisher · View at Google Scholar · View at Scopus
  49. J. S. Whelan, R. C. Jinks, A. McTiernan et al., “Survival from high-grade localised extremity osteosarcoma: combined results and prognostic factors from three European Osteosarcoma Intergroup randomised controlled trials,” Annals of Oncology, vol. 23, no. 6, pp. 1607–1616, 2012. View at Publisher · View at Google Scholar · View at Scopus
  50. M. Collins, M. Wilhelm, R. Conyers et al., “Benefits and adverse events in younger versus older patients receiving neoadjuvant chemotherapy for osteosarcoma: findings from a meta-analysis,” Journal of Clinical Oncology, vol. 31, no. 18, pp. 2303–2312, 2013. View at Publisher · View at Google Scholar · View at Scopus
  51. G. Bacci, S. Ferrari, A. Longhi et al., “High-grade osteosarcoma of the extremity: differences between localized and metastatic tumors at presentation,” Journal of Pediatric Hematology/Oncology, vol. 24, no. 1, pp. 27–30, 2002. View at Publisher · View at Google Scholar · View at Scopus
  52. S. P. Scully, M. A. Ghert, D. Zurakowski, R. C. Thompson, and M. C. Gebhardt, “Pathologic fracture in osteosarcoma: prognostic importance and treatment implications,” The Journal of Bone and Joint Surgery. American Volume, vol. 84, no. 1, pp. 49–57, 2002. View at Google Scholar · View at Scopus
  53. G. Saeter, J. Høie, A. E. Stenwig, A. K. Johansson, E. Hannisdal, and O. P. Solheim, “Systemic relapse of patients with osteogenic sarcoma. Prognostic factors for long term survival,” Cancer, vol. 75, no. 5, pp. 1084–1093, 1995. View at Publisher · View at Google Scholar
  54. B. Kempf-Bielack, S. S. Bielack, H. Jürgens et al., “Osteosarcoma relapse after combined modality therapy: An analysis of unselected patients in the Cooperative Osteosarcoma Study Group (COSS),” Journal of Clinical Oncology, vol. 23, no. 3, pp. 559–568, 2005. View at Publisher · View at Google Scholar · View at Scopus
  55. G. Bacci, C. Forni, A. Longhi et al., “Local recurrence and local control of non-metastatic osteosarcoma of the extremities: a 27-year experience in a single institution,” Journal of Surgical Oncology, vol. 96, no. 2, pp. 118–123, 2007. View at Publisher · View at Google Scholar · View at Scopus
  56. D. Carrle and S. Bielack, “Osteosarcoma lung metastases detection and principles of multimodal therapy,” Cancer Treatment and Research, vol. 152, pp. 165–184, 2009. View at Publisher · View at Google Scholar · View at Scopus
  57. M. Franke, J. Hardes, K. Helmke et al., “Solitary skeletal osteosarcoma recurrence. Findings from the Cooperative Osteosarcoma Study Group,” Pediatric Blood and Cancer, vol. 56, no. 5, pp. 771–776, 2011. View at Publisher · View at Google Scholar · View at Scopus
  58. S. Ferrari, A. Briccoli, M. Mercuri et al., “Late relapse in osteosarcoma,” Journal of Pediatric Hematology/Oncology, vol. 28, no. 7, pp. 418–422, 2006. View at Publisher · View at Google Scholar · View at Scopus
  59. G. Rosen, C. Tan, A. Sanmaneechai, E. J. Beattie Jr., R. Marcove, and M. L. Murphy, “The rationale for multiple drug chemotherapy in the treatment of osteogenic sarcoma,” Cancer, vol. 35, no. 3, supplement, pp. 936–945, 1975. View at Publisher · View at Google Scholar · View at Scopus
  60. A. R. Feinstein, D. M. Sosin, and C. K. Wells, “The Will Rogers phenomenon. Stage migration and new diagnostic techniques as a source of misleading statistics for survival in cancer,” The New England Journal of Medicine, vol. 312, no. 25, pp. 1604–1608, 1985. View at Publisher · View at Google Scholar · View at Scopus
  61. G. Bacci, S. Ferrari, L. Sangiorgi et al., “Prognostic significance of serum lactate dehydrogenase in patients with osteosarcoma of the extremities,” Journal of Chemotherapy, vol. 6, no. 3, pp. 204–210, 1994. View at Google Scholar · View at Scopus
  62. S. Ferrari, G. Bacci, P. Picci et al., “Long-term follow-up and post-relapse survival in patients with non-metastatic osteosarcoma of the extremity treated with neoadjuvant chemotherapy,” Annals of Oncology, vol. 8, no. 8, pp. 765–771, 1997. View at Publisher · View at Google Scholar · View at Scopus
  63. G. Bacci, A. Longhi, S. Ferrari et al., “Prognostic significance of serum alkaline phosphatase in osteosarcoma of the extremity treated with neoadjuvant chemotherapy: recent experience at Rizzoli Institute,” Oncology Reports, vol. 9, no. 1, pp. 171–175, 2002. View at Google Scholar
  64. G. Bacci, A. Longhi, M. Versari, M. Mercuri, A. Briccoli, and P. Picci, “Prognostic factors for osteosarcoma of the extremity trerated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution,” Cancer, vol. 106, no. 5, pp. 1154–1161, 2006. View at Publisher · View at Google Scholar · View at Scopus
  65. P. A. Meyers, G. Heller, J. H. Healey et al., “Osteogenic sarcoma with clinically detectable metastasis at initial presentation,” Journal of Clinical Oncology, vol. 11, no. 3, pp. 449–453, 1993. View at Google Scholar · View at Scopus
  66. M. B. Harris, P. Gieser, A. M. Goorin et al., “Treatment of metastatic osteosarcoma at diagnosis: a Pediatric Oncology Group Study,” Journal of Clinical Oncology, vol. 16, no. 11, pp. 3641–3648, 1998. View at Google Scholar · View at Scopus
  67. G. Bacci, A. Briccoli, M. Rocca et al., “Neoadjuvant chemotherapy for osteosarcoma of the extremities with metastases at presentation: recent experience at the Rizzoli Institute in 57 patients treated with cisplatin, doxorubicin, and a high dose of methotrexate and ifosfamide,” Annals of Oncology, vol. 14, no. 7, pp. 1126–1134, 2003. View at Publisher · View at Google Scholar · View at Scopus
  68. V. Mialou, T. Philip, C. Kalifa et al., “Metastatic osteosarcoma at diagnosis: prognostic factors and long-term outcome—the French pediatric experience,” Cancer, vol. 104, no. 5, pp. 1100–1109, 2005. View at Publisher · View at Google Scholar · View at Scopus
  69. L. Kager, A. Zoubek, U. Pötschger et al., “Primary metastatic osteosarcoma: presentation and outcome of patients treated on neoadjuvant cooperative osteosarcoma study group protocols,” Journal of Clinical Oncology, vol. 21, no. 10, pp. 2011–2018, 2003. View at Publisher · View at Google Scholar · View at Scopus
  70. G. Bacci, M. Rocca, M. Salone et al., “High grade osteosarcoma of the extremities with lung metastases at presentation: treatment with neoadjuvant chemotherapy and simultaneous resection of primary and metastatic lesions,” Journal of Surgical Oncology, vol. 98, no. 6, pp. 415–420, 2008. View at Publisher · View at Google Scholar · View at Scopus
  71. R. J. Grimer, S. R. Cannon, A. M. Taminiau et al., “Osteosarcoma over the age of forty,” European Journal of Cancer, vol. 39, no. 2, pp. 157–163, 2003. View at Publisher · View at Google Scholar · View at Scopus
  72. T. Ozaki, S. Flege, U. Liljenqvist et al., “Osteosarcoma of the spine: experience of the Cooperative Osteosarcoma Study Group,” Cancer, vol. 94, no. 4, pp. 1069–1077, 2002. View at Publisher · View at Google Scholar · View at Scopus
  73. G. Rosen, R. C. Marcove, B. Caparros, A. Nirenberg, C. Kosloff, and A. G. Huvos, “Primary osteogenic sarcoma. The rationale for preoperative chemotherapy and delayed surgery,” Cancer, vol. 43, no. 6, pp. 2163–2177, 1979. View at Publisher · View at Google Scholar
  74. S. S. Bielack, “Osteosarcoma: time to move on?” European Journal of Cancer, vol. 46, no. 11, pp. 1942–1945, 2010. View at Publisher · View at Google Scholar · View at Scopus
  75. D. S. Geller and R. Gorlick, “Osteosarcoma: a review of diagnosis, management, and treatment strategies,” Clinical Advances in Hematology and Oncology, vol. 8, no. 10, pp. 705–718, 2010. View at Google Scholar · View at Scopus