Research Article
Prognostic Factors and Treatment Results of High-Grade Osteosarcoma in Norway: A Scope Beyond the “Classical” Patient
Table 2
Relative risk analysis among nonclassical osteosarcoma (OS) patients; primary metastatic disease, nonextremity localisation, and age >40 years.
| | Nonclassical OS | Primary metastatic disease | Nonextremity localisation | Age >40 years | RRa (95% CIb) | | | RRa (95% CIb) | | | RRa (95% CIb) | | | RRa (95% CIb) | |
| Axial versus extremity | | | | | | | | | | | | Extremity | | | 61 | 1 | | 0 | | | 59 | 1 | | Axial | | | 23 | 1.0 (0.7–1.5) | 0.953 | 115 | | | 68 | 3.4 (2.5–4.6) | <0.001 | Primary metastatic disease | | | | | | | | | | | | No | | | 0 | | | 89 | 1 | | 94 | 1 | | Yes | | | 84 | | | 23 | 1.0 (0.7–1.5) | 0.857 | 31 | 1.4 (0.9–2.1) | 0.102 | Age | | | | | | | | | | | | ≤40 years | | | 53 | 1 | | 47 | 1 | | 0 | | | >40 years | | | 31 | 1.3 (0.9–1.8) | 0.109 | 68 | 3.1 (2.4–4.1) | <0.001 | 127 | | | Tumour size | | | | | | | | | | | | ≤10 cm | 1 | | 18 | 1 | | 51 | 1 | | 48 | 1 | | >10 cm | 1.1 (0.9–1.4) | 0.436 | 38 | 1.6 (1.3–2.0) | <0.001 | 26 | 0.7 (0.5–1.0) | 0.026 | 42 | 1.0 (0.8–1.3) | 0.870 | Duration of symptoms | | | | | | | | | | | | ≤3 months | 1 | | 43 | 1 | | 35 | 1 | | 41 | 1 | | >3 months | 1.5 (1.2–1.8) | <0.001 | 34 | 0.9 (0.7–1.2) | 0.632 | 61 | 1.6 (1.3–1.9) | <0.001 | 65 | 1.5 (1.2–1.8) | <0.001 | Pathologic fracture | | | | | | | | | | | | No | 1 | | 68 | 1 | | 111 | 1 | | 102 | 1 | | Yes | 1.3 (0.8–2.0) | 0.364 | 16 | 1.5 (0.9–2.4) | 0.124 | 4 | 0.2 (0.1–0.5) | 0.001 | 25 | 1.7 (1.1–2.8) | 0.025 | ALP | | | | | | | | | | | | Normal | 1 | | 18 | 1 | | 34 | 1 | | 34 | 1 | | Elevated | 1.9 (1.4–2.4) | <0.001 | 46 | 1.9 (1.5–2.4) | <0.001 | 43 | 1.4 (1.1–1.8) | 0.017 | 47 | 1.5 (1.1–1.9) | 0.003 | LDH | | | | | | | | | | | | Normal | 1 | | 21 | 1 | | 43 | 1 | | 41 | 1 | | Elevated | 1.3 (1.0–1.6) | 0.098 | 41 | 1.7 (1.4–2.2) | <0.001 | 31 | 0.9 (0.7–1.3) | 0.667 | 37 | 1.1 (0.8–1.5) | 0.473 | Histology | | | | | | | | | | | | Osteoblastic | 1 | | 44 | 1 | | 48 | 1 | | 51 | 1 | | Chondroblastic | 1.0 (0.9–1.1) | 0.622 | 8 | 1.1 (1.0–1.3) | 0.124 | 20 | 0.9 (0.7–1.0) | 0.135 | 18 | 0.9 (0.8–1.1) | 0.404 | Fibroblastic | 1.0 (0.9–1.1) | 0.816 | 8 | 1.0 (0.9–1.2) | 0.610 | 9 | 1.0 (0.9–1.2) | 0.656 | 13 | 1.0 (0.8–1.1) | 0.530 | Other | 0.9 (0.8–1.1) | 0.423 | 23 | 1.1 (0.9–1.4) | 0.270 | 38 | 0.9 (0.8–1.2) | 0.476 | 44 | 0.9 (0.7–1.1) | 0.220 |
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Relative risk, bconfidence interval, value, and dnumber of patients.
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