Mesenchymal Chondrosarcoma in Children and Young Adults: A Single Institution Retrospective Review

Table 1

Characteristics, treatment, and outcome of children and adolescents with mesenchymal chondrosarcoma.

Patient	Age (yr)	Sex	Primary site	Size (cm)	Osseous versus extraosseous	Neoadjuvant therapy	Response (RECIST)	Response (volumetric)	Extent of surgery	Adjuvant therapy	Outcome (yr)
1	15.2	F	Abdominal mesentery	12.7	Extraosseous	—	—		CR	RT (55.2 Gy); CH (I, D)	NED (0.7)
2	14.5	F	Chest wall	2.5	Osseous	—	—		+margin	Brachytherapy (15 Gy); RT (45 Gy)	NED (8.7)
3	19.7	F	Pterygopalatine fossa	5.3	Extraosseous	—	—		+margin	RT (59.4 Gy)	AWD (1.3)
4	13.9	F	Maxillary sinus	5.3	Osseous	—	—		+margin	CH (I, D); RT (55.8 Gy)	NED (0.3)
5	1.3	F	Paraspinal	6.0	Extraosseous	—	—		Gross residual disease	RT (60.7 Gy); CH (I, C)	Died (8.1), renal failure
6	17.3	F	Maxilla	5.5	Osseous	CH (I, D, V); RT (50 Gy)	SD	SD	CR	RT (20 Gy)	NED (10.7)
7	11.7	M	Chest wall	10.4	Osseous	CH (I, D, V, E)	SD	SD	CR	CH (I, D, V, E); RT (55.8 Gy)	NED (5.3)
8	9.8	F	Orbit	2.5	Extraosseous	CH (I, D); RT (45 Gy)	SD	SD	CR	CH (I, D)	NED (6.8)
9	17.4	F	Orbit	2.1	Extraosseous	CH (I, D); RT (45 Gy)	SD	PR	CR	CH (I, D)	NED (6.1)
10	12.8	F	Intraspinal	3.1	Extraosseous	CH (I, D); RT (45 Gy)	PD	SD	+margin	CH (I, D); RT (10.8 Gy)	AWD (4.3)
11	12.1	M	Nasal cavity	6.5	Extraosseous	CH (I, D)	SD	SD	+margin	RT (59.4 Gy)	NED (1.2)
12	16.5	M	Chest wall	2.5	Osseous	—	—		Primary resected	CH (I, D)	DOD (1.3)

Patient received one cycle of neoadjuvant chemotherapy only; Primary tumor grossly resected, unable to be cleared of metastatic lung nodules. RT: radiotherapy; Gy: Gray; CH: chemotherapy; I: ifosfamide; D: doxorubicin; C: carboplatin; V: vincristine; E: etoposide; SD: stable disease; PR: partial response; CR: complete resection; NED: no evidence of disease; AWD: alive with disease; DOD: died of disease.