Review Article

The Identification of Prognostic Factors and Survival Statistics of Conventional Central Chondrosarcoma

Table 7

Prognostic factors.

Andreou et al. [15]
Overall survival

Variable (bivariate analysis) value
Sex
Age (higher)
Extremity versus axial  + pelvis
Tumor volume (0–100 cc vs. >100 cc)
Grade tumor
Local recurrences
Distant metastasis
Surgical margins
Type of surgery
 Low grade: ablative versus limb-sparing
 High grade: ablative versus limb-sparing
Pathologic fracture
ACJCC
Multi disc. versus support. care
Variable (multivariate analysis)
High grade: RR = 5
Axial + pelvis: RR = 2

Staals et al. [25]
Disease-free survival

Variable (bivariate analysis) value
GenderNS
AgeNS
Duration of symptomsNS
Lesion sizeNS
Anatomic locationNS
Stage 3 versus Stage 2a
Stage 3 versus Stage 2b
Stage 2a versus Stage 2b
Histologic subtype, MFH versus OS
Histologic subtype, MFH versus fibr. sarc.
Histologic subtype, OS versus fibr. sarc.
Grade 3DD versus grade 4DD
Percentage of DD component
Percentage of DD component, >50% versus <50%
Limb-sparing versus resection
Surgery versus surgery + chemotherapy
Variable (multivariate analysis, overall survival)
Percentage of DD component

Angelini et al. [16]
Overall survival

Variable (bivariate analysis) value
G1: wide versus intralesional
G1: extremity versus trunk
G2: wide versus intralesional
G2: extremity versus trunk
G2: resect. versus amputation
G3: extremity versus trunk
G3: resect. versus amputation
Variable (multivariate analysis)
G3: resect. versus amputation
G3: extr. versus trunk

van Maldegem et al. [26]
Overall survival from the day of unresectability

Variable (bivariate analysis) value
Only local unresectable disease versus local unresectable disease + metastasis
Age (<40 years)
Grade II tumors
SexNS
SiteNS
Resectable versus nonresectable disease at primary diagnosisNS
Systemic treatment

RR = Relative Risk, G = grade, MFH = malignant fibrohistocytoma, OS = osteosarcoma, and DD = dedifferentiated.