Medication Exposures and Subsequent Development of Ewing Sarcoma: A Review of FDA Adverse Event Reports

Table 2

Characteristics of 25 FDA case reports of pre-ESFT drug exposures.

	Age/sex	Disease	latency	Site	Drug	Type	Concomitant meds	Other
1	13 f	Crohn’s	>2 yrs	Pelvis	Infliximab	Immune	None reported
2	26 f	Crohn’s	4 yrs	Calf	Infliximab	Immune	Mesalamine, GH	Severe Crohn’s, registry azathioprine lansoprazole
3	39 m	Crohn’s	2.5 yrs	Unknown	Infliximab	Immune	Mesalamine, Azathioprine
4	f	MS	9-10 mos	Clavicle	Interferon	Immune	Potassium	pmh: clavicle fibrodysplasia, beta-1A, FMH positive for cancer
5	68 f	MS	>5 yrs	Shoulder	Interferon	Immune	No information	beta-1A
6	54 f	MS	3 mos	Brain	Natalizumab	immune	No information
7	m	Ankylosing spondylitis	unknown	Unknown	Infliximab	Immune	No information
8	50 f	RA	4 yrs	Unknown	Etanercept	Immune	No information	Canada
9	20 m	Psoriasis	6 yrs	Unknown	Infliximab	Immune	Methotrexate, cyclosporine, etanercept	Acitretin, efalizumab >6 yrs
10	52 m	transplant	8 yrs	Abdomen	Cyclosporine	Immune	steroids, azathioprine	Lliterature case [18] patient had OKT3 ab; 2 transplants, nephrosclerosis
11	65 m	Chronic hepatitis C	12 yrs	Unknown	Peginterferon	Immune		Cholecystectomy, cirrhosis, esophageal varices alfa-2b and ribavirin
12	5 f	Nephrotic sx	18 mos	Spine	Cyclosporine	Immune	Dipyramidole, warfarin, prednisolone, cyclosporin
13	11 f	GH def	18 mos	Thigh	r-somatropin	Hormone		Dose 0.7 mg sq should have been 0.47
14	16 f	GH def	Unknown	Clavicle	r-somatropin	Hormone		Patient grew 2.5 cm after GH
15	47 f	Menopause	10 mos	Spine	Estrogen/progestin	hormone	No information	Medical history—negative
16	24 f	Contraception	2.5 yrs	Unknown	Etonogestrel	Hormone	No information	Patient wt 268 lbs, ht 66.9′′, BMI = 42
17	49 f	Osteoporosis	4 mos	Shoulder	Teriparatide	Hormone		Other osteoporosis drugs, family history—breast cancer
18	17 m	Unspecified psychiatric condition	unknown	Unknown	Olanzapine	Psychotropic	Acetaminophen
19	19 m	Depression	3 mos	Unknown	Olanzapine	Psychotropic	Clonazepam	Unspecified depression
20	8 m	Epilepsy	8 yrs	metastatic	Ethosuximide	Psychotropic	Clobazam, valproic acid	CNS depressant
21	8 f	ADHD	Unknown	Mnknown	Methylphenidate	Psychotropic
22	34 f	Narcolepsy	22 mos	Unknown	Sodium oxybate	Psychotropic	None
23	42 f	Sciatica	Unknown	Unknown	Pregabalin	Psychotropic	Lisinopril for high blood pressure	Fibromyalgia, CNS depressant; peripheral neuropathy
24	24 f	Acne	10 mos	Unknown	Isotretinoin	Others	No information
25	9 m	High cholesterol	23 mos	Mandible	Atorvastatin	Cholesterol Lowering	Ezetimibe	3-year trial