Sarcoma / 2015 / Article / Tab 2

Review Article

Medication Exposures and Subsequent Development of Ewing Sarcoma: A Review of FDA Adverse Event Reports

Table 2

Characteristics of 25 FDA case reports of pre-ESFT drug exposures.

Age/sexDiseaselatencySiteDrugTypeConcomitant medsOther

1 13 fCrohn’s>2 yrsPelvisInfliximabImmuneNone reported
226 fCrohn’s4 yrsCalfInfliximabImmuneMesalamine, GHSevere Crohn’s, registry azathioprine lansoprazole
339 mCrohn’s 2.5 yrs UnknownInfliximabImmuneMesalamine, Azathioprine
4 fMS9-10 mosClavicleInterferonImmunePotassiumpmh: clavicle fibrodysplasia, beta-1A, FMH positive for cancer
568 fMS>5 yrsShoulder InterferonImmuneNo informationbeta-1A
654 fMS3 mos BrainNatalizumabimmuneNo information
7 mAnkylosing spondylitis unknownUnknownInfliximabImmuneNo information
850 fRA4 yrsUnknownEtanerceptImmuneNo information Canada
920 mPsoriasis6 yrsUnknownInfliximabImmuneMethotrexate, cyclosporine, etanerceptAcitretin, efalizumab >6 yrs
1052 mtransplant8 yrsAbdomenCyclosporineImmunesteroids, azathioprineLliterature case [18] patient had OKT3 ab
2 transplants, nephrosclerosis
1165 mChronic hepatitis C 12 yrsUnknownPeginterferonImmuneCholecystectomy, cirrhosis, esophageal varices alfa-2b and ribavirin
125 fNephrotic sx 18 mosSpineCyclosporine ImmuneDipyramidole, warfarin, prednisolone, cyclosporin
1311 fGH def18 mos Thighr-somatropinHormoneDose 0.7 mg sq should have been 0.47
1416 fGH def UnknownClavicler-somatropin HormonePatient grew 2.5 cm after GH
1547 fMenopause10 mosSpine Estrogen/progestin hormoneNo information Medical history—negative
1624 fContraception2.5 yrs UnknownEtonogestrelHormoneNo information Patient wt 268 lbs, ht 66.9′′, BMI = 42
1749 fOsteoporosis4 mosShoulderTeriparatideHormoneOther osteoporosis drugs, family history—breast cancer
1817 mUnspecified psychiatric conditionunknownUnknownOlanzapinePsychotropicAcetaminophen
1919 mDepression 3 mosUnknownOlanzapinePsychotropic ClonazepamUnspecified depression
208 mEpilepsy8 yrsmetastatic EthosuximidePsychotropicClobazam, valproic acidCNS depressant
218 fADHDUnknownMnknownMethylphenidatePsychotropic
2234 fNarcolepsy22 mosUnknownSodium oxybate PsychotropicNone
2342 fSciaticaUnknownUnknownPregabalinPsychotropicLisinopril for high blood pressure Fibromyalgia, CNS depressant
peripheral neuropathy
2424 fAcne10 mosUnknownIsotretinoinOthersNo information
259 mHigh cholesterol23 mosMandibleAtorvastatinCholesterol Lowering Ezetimibe3-year trial

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