Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma

Figure 1

Cancer cachexia in osteosarcoma-bearing mice. (a) Six weeks after the injection of K7M2 cells into tibias of mice, tumor development can be observed in right hindlimb (green arrow). The tumor-bearing mice showed smaller muscle size (outlined with rectangle) and reduced adipose tissue (outlined with circles). (b) Left hindlimbs from mice with and without tumor. (c) Gastrocnemius (GM) muscles from mice with and without tumor.

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