Notch Signaling Mediates Skeletal Muscle Atrophy in Cancer Cachexia Caused by Osteosarcoma

Figure 2

Skeletal muscle from tumor-carrying mice developed muscle atrophy. (a) H&E staining of GM muscles, revealing relative myofiber size and number of mononuclear cells (i.e., macrophages or undifferentiated muscle stem cells) in mice with and without tumor. mice in each group. (b) Trichrome staining of GM muscles, demonstrating differential myofiber size and collagen deposition. mice in each group. (c) Myofiber size in GM muscles. (d) Collagen deposition in GM muscles. “” in the bar chart indicates .

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