Clinical Study

Concurrent Imatinib and Radiation Therapy for Unresectable and Symptomatic Desmoid Tumors

Table 2

Selected previous studies of desmoid tumors treated with imatinib or radiation therapy alone.

ManuscriptToxicityLocal control

Imatinib alone
Heinrich et al. 2006 [8]≥50% grade 336.8% at 1 year
Chugh et al. 2010 [7]≥9.8% grade 3/466% at 1 year
Penel et al. 2011 [9]45% grade 367% at 1 year

Radiation alone
Nuyttens et al. 2000 [10]22.8% total78% at 6 years
Guadagnolo et al. 2008 [11]10.5% moderate, 4.3% severe68% at 10 years
Keus et al. 2013 [19]4.5% grade 381.5% at 3 years