Evaluation of Quality of Life at Progression in Patients with Soft Tissue Sarcoma
Table 1
Patients’ baseline characteristics of cross-sectional population for QoL analysis.
Demographic items
Eribulin ()
DAC ()
Total ()
value
Age (years)
223
219
442
0.263
Mean (SD)
55.5 (11.09)
55.7 (10.46)
55.6 (10.77)
Median
56.0
56.0
56.0
Min, Max
28.0, 83.0
24.0, 83.0
24.0, 83.0
Gender
Male
65 (29.1%)
79 (36.1%)
144 (32.6%)
0.120
Female
158 (70.9%)
140 (63.9%)
298 (67.4%)
Race
White
158 (70.9%)
164 (74.9%)
322 (72.9%)
0.865
Black or African American
6 (2.7%)
6 (2.7%)
12 (2.7%)
Japanese
1 (0.4%)
0 (0.0%)
1 (0.2%)
Chinese
2 (0.9%)
1 (0.5%)
3 (0.7%)
Other Asian
15 (6.7%)
15 (6.8%)
30 (6.8%)
Native Hawaiian or other Pacific Islander
1 (0.4%)
0 (0.0%)
1 (0.2%)
Other
6 (2.7%)
4 (1.8%)
10 (2.3%)
Missing
33 (15.2%)
29 (13.2%)
63 (14.3%)
Region
USA and Canada
85 (38.1%)
84 (38.4%)
169 (38.2%)
0.998
Western Europe, Australasia, and Israel
104 (46.6%)
102 (46.6%)
206 (46.6%)
Eastern Europe, Latin America, and Asia
34 (15.2%)
33 (15.1%)
67 (15.2%)
ECOG PS
223
219
442
0.661
Mean (SD)
0.5 (0.53)
0.7 (0.58)
0.6 (0.56)
Median
1.0
1.0
1.0
Min, Max
0.0, 2.0
0.0, 2.0
0.0, 2.0
NYHA
Class I
144 (64.6%)
130 (59.4%)
274 (62.0%)
0.353
Class II
15 (6.7%)
19 (8.7%)
34 (7.7%)
Prior regimens
Number of prior regimens for advanced STS: 2
120 (53.8%)
120 (54.8%)
240 (54.3%)
0.836
Number of prior regimens for advanced STS: >2
103 (46.2%)
99 (45.2%)
202 (45.7%)
Histology/cytology
Liposarcoma
70 (31.4%)
71 (32.4%)
140 (31.9%)
0.816
Leiomyosarcoma
153 (68.6%)
148 (67.6%)
301 (68.1%)
CSP, cross-sectional population; DAC, dacarbazine; ECOG PS, Eastern Cooperative Oncology Group Performance Status; NYHA, New York Heart Association; SD, standard deviation; STS, soft tissue sarcoma. Of note, of the 452 patients randomized, only 442 patients (223 patients in the eribulin treatment arm and 219 patients in the DAC treatment arm) were included in the cross-sectional population (defined as any full analysis set patient with at least one item of QLQ-C30 or EQ-5D questionnaire at the time of randomization). From -test on continuous variable or Chi-square test on categorical variables.
