Predictors of Wound Complications following Radiation and Surgical Resection of Soft Tissue Sarcomas

Table 2

Treatment characteristics.

Characteristic	Major wound complication			Any wound complication
	Yes	No		Yes	No
Resection type			1.0			0.76
Primary resection	11 (79%)	43 (81%)		17 (77%)	37 (82%)
Reresection	3 (21%)	10 (19%)		5 (23%)	8 (18%)
Wound closure			0.19			0.01
Primary	6 (43%)	33 (62%)		8 (36%)	31 (69%)
Skin graft and/or vascularized flap reconstruction	8 (57%)	20 (38%)		14 (64%)	14 (31%)
Preoperative chemotherapy			1.0			0.48
Yes	4 (29%)	15 (28%)		5 (23%)	14 (31%)
No	10 (71%)	38 (72%)		17 (77%)	31 (69%)
Institution providing radiation therapy			0.6			0.39
Our institution	12 (86%)	49 (92%)		19 (87%)	42 (93%)
Other	2 (14%)	4 (8%)		3 (13%)	3 (7%)
Radiation modality			0.74			0.008
3D conformal	4 (29%)	13 (25%)		10 (45%)	7 (16%)
IMRT	10 (71%)	30 (57%)		12 (55%)	28 (62%)
Proton therapy	0 (0%)	10 (18%)		0 (0)	10 (22%)
Radiation timing			0.43			0.72
Preoperative	11 (79%)	46 (87%)		18 (82%)	39 (87%)
Postoperative	3 (21%)	7 (13%)		4 (18%)	6 (13%)
Use of radiation boost			1.0			1.0
Yes	1 (8%)	5 (10%)		2 (10%)	4 (9%)
No	12 (92%)	46 (90%)		19 (90%)	39 (91%)
Use of radiation bolus			0.5			0.16
Yes	5 (36%)	12 (24%)		8 (38%)	9 (21%)
No	9 (64%)	37 (76%)		13 (62%)	33 (79%)
Grade ≥2 radiation dermatitis			0.51			0.02
Yes	5 (36%)	13 (25%)		10 (45%)	8 (19%)
No	9 (64%)	38 (75%)		12 (55%)	35 (81%)
Cumulative radiation dose (gy)	5027 (410)	5015 (296)	0.85	5021 (323)	5016 (323)	0.34
Radiation planning target volume (cc)	1646 (1526)	1314 (1663)	0.12	1747 (2382)	1206 (1092)	0.53

Continuous variables are reported as mean (SD). Categorical variables are reported as (%). Total count values may not sum to 67 due to missing data. Bolded values correspond to covariates that met a level of significance of for inclusion in the multivariable model. IMRT: intensity-modulated radiation therapy. gy: gray. cc: cubic centimeters.