Pasteurized Autograft-Prosthesis Composite Reconstruction May Not Be a Viable Primary Procedure for Large Skeletal Defects after Resection of Sarcoma

Table 3

Associations between clinical variables and pasteurized bone-prosthesis composite survival.

Variables	Univariate		Multivariate
	20 y EFSR	value	RR	95% CI	value
Age
≤14, >40	56.9 ± 11.2	0.47	ND	ND	ND
15–40	40.9 ± 9.4
Gender
Female	66.0 ± 8.9	0.01	1
Male	31.1 ± 10.5		2.047	1.05–4.00	0.021
Initial tumor volume
≤200 ml	40.7 ± 12.9	0.002	1
>200 ml	44.3 ± 9.4		3.550	1.90–6.63	0.001
Location
Femur, humerus	67.1 ± 6.3	0.003	1
Pelvis, tibia	0		1.951	1.07–3.55	0.029
Pasteurization length
>10 cm	52.5 ± 6.8	0.02	1
≤10 cm	18.6 ± 14.3		2.785	1.47–5.29	0.002
Mode of fixation
Cemented	37.0 ± 11.9	0.05	1
Noncemented	33.3 ± 12.1		1.579	0.77–3.25	0.215
Use of chemotherapy
Chemotherapy	38.2 ± 12.1	0.94	ND	ND	ND
Operation only	35.0 ± 16.5
Total	42.6 ± 9.2

10 y EFSR = 10-year event-free survival rate; RR = relative risk; CI = confidence interval; ND = not done.