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Sarcoma
Volume 2018, Article ID 2640674, 12 pages
https://doi.org/10.1155/2018/2640674
Review Article

Role of High-Dose Chemotherapy and Autologous Hematopoietic Cell Transplantation for Children and Young Adults with Relapsed Ewing’s Sarcoma: A Systematic Review

1Department of Medicine, University of Arizona, Tucson, AZ 85721, USA
2Department of Biostatics, Mel and Enid Zuckerman College of Public Health, University of Arizona, Tucson, AZ 85721, USA
3Division of Hematology and Oncology, Department of Medicine, University of Arizona, Tucson, AZ 85721, USA
4Malignant Hematology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, FL 33612, USA

Correspondence should be addressed to Faiz Anwer; ude.anozira.liame@frewna

Received 30 January 2018; Revised 24 April 2018; Accepted 13 May 2018; Published 3 June 2018

Academic Editor: Valerae O. Lewis

Copyright © 2018 Pavan Tenneti et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. M. Paulussen, S. Bielack, H. Jurgens et al., “Ewing’s sarcoma of the bone: ESMO clinical recommendations for diagnosis, treatment and follow-up,” Annals of Oncology, vol. 20, no. 4, pp. 140–142, 2009. View at Publisher · View at Google Scholar · View at Scopus
  2. M. Stahl, A. Ranft, M. Paulussen et al., “Risk of recurrence and survival after relapse in patients with Ewing sarcoma,” Pediatric Blood and Cancer, vol. 57, no. 4, pp. 549–553, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Bacci, S. Ferrari, A. Longhi et al., “Therapy and survival after recurrence of Ewing’s tumors: the Rizzoli experience in 195 patients treated with adjuvant and neoadjuvant chemotherapy from 1979 to 1997,” Annals of Oncology, vol. 14, no. 11, pp. 1654–1659, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. P. J. Leavey, L. Mascarenhas, N. Marina et al., “Prognostic factors for patients with Ewing sarcoma (EWS) at first recurrence following multi-modality therapy: a report from the Children’s Oncology Group,” Pediatric Blood and Cancer, vol. 51, no. 3, pp. 334–338, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Rodriguez-Galindo, C. A. Billups, L. E. Kun et al., “Survival after recurrence of Ewing tumors: the St Jude Children’s Research Hospital experience, 1979-1999,” Cancer, vol. 94, no. 2, pp. 561–569, 2002. View at Publisher · View at Google Scholar · View at Scopus
  6. F. Navid, J. R. Willert, M. B. McCarville et al., “Combination of gemcitabine and docetaxel in the treatment of children and young adults with refractory bone sarcoma,” Cancer, vol. 113, no. 2, pp. 419–425, 2008. View at Publisher · View at Google Scholar · View at Scopus
  7. P. Van Winkle, A. Angiolillo, M. Krailo et al., “Ifosfamide, carboplatin, and etoposide (ICE) reinduction chemotherapy in a large cohort of children and adolescents with recurrent/refractory sarcoma: the Children’s Cancer Group (CCG) experience,” Pediatric Blood and Cancer, vol. 44, no. 4, pp. 338–347, 2005. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Hunold, N. Weddeling, M. Paulussen et al., “Topotecan and cyclophosphamide in patients with refractory or relapsed Ewing tumors,” Pediatric Blood and Cancer, vol. 47, no. 6, pp. 795–800, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Raciborska, K. Bilska, K. Drabko et al., “Vincristine, irinotecan, and temozolomide in patients with relapsed and refractory Ewing sarcoma,” Pediatric Blood and Cancer, vol. 60, no. 10, pp. 1621–1625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  10. D. A. Casey, L. H. Wexler, M. S. Merchant et al., “Irinotecan and temozolomide for Ewing sarcoma: the Memorial Sloan-Kettering experience,” Pediatric Blood and Cancer, vol. 53, no. 6, pp. 1029–1034, 2009. View at Publisher · View at Google Scholar · View at Scopus
  11. A. M. van Maldegem, C. Benson, P. Rutkowski et al., “Etoposide and carbo-or cisplatin combination therapy in refractory or relapsed Ewing sarcoma: a large retrospective study,” Pediatric Blood and Cancer, vol. 62, no. 1, pp. 40–44, 2015. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Rosenthal and A. B. Pawlowska, “High-dose chemotherapy and stem cell rescue for high-risk Ewing’s family of tumors,” Expert Review of Anticancer Therapy, vol. 11, no. 2, pp. 251–262, 2011. View at Publisher · View at Google Scholar · View at Scopus
  13. S. A. Kalambakas, T. B. Moore, and S. A. Feig, “Megatherapy and stem cell transplantation for Ewing’s family of tumors: a critical review of current literature,” Pediatric Transplantation, vol. 8, no. 5, pp. 83–88, 2004. View at Publisher · View at Google Scholar · View at Scopus
  14. M. Rasper, S. Jabar, A. Ranft, H. Jürgens, S. Amler, and U. Dirksen, “The value of high-dose chemotherapy in patients with first relapsed Ewing sarcoma,” Pediatric Blood and Cancer, vol. 61, no. 8, pp. 1382–1386, 2014. View at Publisher · View at Google Scholar · View at Scopus
  15. A. McTiernan, D. Driver, M. P. Michelagnoli, A. M. Kilby, and J. S. Whelan, “High dose chemotherapy with bone marrow or peripheral stem cell rescue is an effective treatment option for patients with relapsed or progressive Ewing’s sarcoma family of tumours,” Annals of Oncology, vol. 17, no. 8, pp. 1301–1305, 2006. View at Publisher · View at Google Scholar · View at Scopus
  16. L. M. Barker, T. W. Pendergrass, J. E. Sanders, and D. S. Hawkins, “Survival after recurrence of Ewing’s sarcoma family of tumors,” Journal of Clinical Oncology, vol. 23, no. 19, pp. 4354–4362, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Ferrari, R. Luksch, K. Sundby Hall et al., “Post-relapse survival in patients with Ewing sarcoma,” Pediatric Blood Cancer, vol. 62, no. 6, pp. 994–999, 2015. View at Publisher · View at Google Scholar · View at Scopus
  18. E. Palmerini, M. Colangeli, C. Nanni et al., “High-dose chemotherapy with autologous stem cell transplantation for relapsed Ewing’s sarcoma,” Journal of Clinical Oncology, vol. 27, no. 15, p. 10545, 2009. View at Google Scholar
  19. A. G. Shankar, S. Ashley, A. W. Craft, and C. R. Pinkerton, “Outcome after relapse in an unselected cohort of children and adolescents with Ewing sarcoma,” Medical and Pediatric Oncology, vol. 40, no. 3, pp. 141–147, 2003. View at Publisher · View at Google Scholar · View at Scopus
  20. H. Ekert, K. Tiedemann, K. D. Waters, and W. M. Ellis, “Experience with high dose multiagent chemotherapy and autologous bone marrow rescue in the treatment of twenty-two children with advanced tumours,” Australian Paediatric Journal, vol. 20, no. 3, pp. 195–201, 1984. View at Publisher · View at Google Scholar · View at Scopus
  21. J. Graham-Pole, H. M. Lazarus, R. H. Herzig et al., “High-dose melphalan therapy for the treatment of children with refractory neuroblastoma and Ewing's sarcoma,” American Journal of Pediatric Hematology/Oncology, vol. 6, no. 1, pp. 17–26, 1984. View at Google Scholar
  22. S. Burdach, H. Jürgens, C. Peters et al., “Myeloablative radiochemotherapy and hematopoietic stem-cell rescue in poor-prognosis Ewing’s sarcoma,” Journal of Clinical Oncology, vol. 11, no. 8, pp. 1482–1488, 1993. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Perentesis, E. Katsanis, T. E. DeFor, J. P. Neglia, and N. K. C. Ramsay, “Autologous stem cell transplantation for high-risk pediatric solid tumors,” Bone Marrow Transplantation, vol. 24, no. 6, pp. 609–615, 1999. View at Publisher · View at Google Scholar
  24. K. Jahnukainen, P. Kallio, A. Koivusalo, and U. M. Saarinen-Pihkala, “High-dose thiotepa as consolidation therapy with autologous hematopoietic stem cell transplantation for high-risk Ewing family tumors: Single-institution experience,” Journal of Pediatric Hematology/Oncology, vol. 37, no. 7, pp. 536–542, 2015. View at Publisher · View at Google Scholar · View at Scopus
  25. J. Seo, D. H. Kim, J. S. Lim et al., “High-dose chemotherapy and autologous peripheral blood stem cell transplantation in the treatment of children and adolescents with ewing sarcoma family of tumors,” Korean Journal of Pediatrics, vol. 56, no. 9, pp. 401–406, 2013. View at Publisher · View at Google Scholar · View at Scopus
  26. J. Rosenthal, E. Bolotin, M. Shakhnovits et al., “High-dose therapy with hematopoietic stem cell rescue in patients with poor prognosis Ewing family tumors,” Bone Marrow Transplantation, vol. 42, no. 5, pp. 311–318, 2008. View at Publisher · View at Google Scholar · View at Scopus
  27. B. Frohlich, S. Ahrens, S. Burdach et al., “High-dosage chemotherapy in primary metastasized and relapsed Ewing’s sarcoma,” Klinische Pädiatrie, vol. 211, no. 4, pp. 284–290, 1999. View at Publisher · View at Google Scholar
  28. H. Juergens, A. Ranft, M. Paulussen et al., “Treosulfan-based high-dose chemotherapy with autologous stem cell transplantation in high-risk Ewing sarcoma,” Journal of Clinical Oncology, vol. 27, no. 15, p. 10546, 2009. View at Google Scholar
  29. N. Al-Faris, T. Al Harbi, C. Goia, A. Pappo, J. Doyle, and A. Gassas, “Does consolidation with autologous stem cell transplantation improve the outcome of children with metastatic or relapsed Ewing sarcoma?” Pediatric Blood and Cancer, vol. 49, no. 2, pp. 190–195, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. C. J. Fraser, B. J. Weigel, J. P. Perentesis et al., “Autologous stem cell transplantation for high-risk Ewing’s sarcoma and other pediatric solid tumors,” Bone Marrow Transplantation, vol. 37, no. 2, pp. 175–181, 2006. View at Publisher · View at Google Scholar · View at Scopus
  31. H. Pape, H.-J. Laws, S. Burdach et al., “Radiotherapy and high-dose chemotherapy in advanced Ewing’s tumors,” Strahlentherapie und Onkologie, vol. 175, no. 10, pp. 484–487, 1999. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Kavan, J. Novotny, E. Kabickova et al., “High dose chemotherapy in children with Ewing sarcoma and peripheral neuroectodermal tumor,” Klinicka Onkologie, vol. 12, pp. 120–123, 1999. View at Google Scholar
  33. R. Ladenstein, T. Philip, C. Lasset et al., “Impact of megatherapy in children with high-risk Ewing’s tumours in complete remission: a report from the EBMT Solid Tumour Registry,” Bone Marrow Transplant, vol. 15, no. 5, pp. 697–705, 1995. View at Google Scholar
  34. R. Elhasid, M. W. B. Arush, S. Postovsky et al., “Autologous stem cell transplantation in Ewing’s sarcoma: the experience of Rambam medical centre and Tel Aviv medical centre,” Bone Marrow Transplantation, vol. 47, pp. S425–S426, 2012. View at Google Scholar
  35. L. M. Cristofani, M. T. Almeida, and J. Fernandes, “Megachemotherapy with hematopoietic stem cell rescue for the treatment of children with advanced solid tumors,” Pediatric Transplantation, vol. 17, no. 2, p. 192, 2013. View at Google Scholar
  36. U. Thiel, A. Wawer, I. Teichert et al., “Stem cell rescue from irradiation of multiple tumor sites combined with high-dose chemotherapy, followed by reduced intensity conditioning and haplodisparate stem cell transplantation in patients with advanced pediatric sarcomas: preliminary results,” Bone Marrow Transplantation, vol. 49, p. S207, 2014. View at Google Scholar
  37. J. S. Miser and J. E. Sanders, “High-dose chemotherapy and systemic adjuvant irradiation in Ewing’s sarcoma,” Bone Marrow Transplantation, vol. 14, no. 1, p. S54, 1994. View at Google Scholar
  38. E. Frei and G. P. Canellos, “Dose: a critical factor in cancer chemotherapy,” American Journal of Medicine, vol. 69, no. 4, pp. 585–594, 1980. View at Publisher · View at Google Scholar · View at Scopus
  39. R. C. Seeger and C. P. Reynolds, “Treatment of highrisk solid tumors of childhood with intensive therapy and autologous bone marrow transplantation,” Pediatric Clinics of North America, vol. 38, no. 2, pp. 393–424, 1991. View at Publisher · View at Google Scholar · View at Scopus
  40. U. De Giorgi, S. Richard, M. Badoglio et al., “Salvage high-dose chemotherapy in female patients with relapsed/refractory germ cell tumors: a retrospective analysis of the European Group for Blood and Marrow Transplantation (EBMT),” Annals of Oncology, vol. 28, no. 8, pp. 1910–1916, 2017. View at Publisher · View at Google Scholar · View at Scopus
  41. F. Petrelli, A. Coinu, G. Rosti, P. Pedrazzoli, and S. Barni, “Salvage treatment for testicular cancer with standard- or high-dose chemotherapy: a systematic review of 59 studies,” Medical Oncology, vol. 34, no. 8, p. 133, 2017. View at Publisher · View at Google Scholar · View at Scopus
  42. J. A. Child, G. J. Morgan, F. E. Davies et al., “High-dose chemotherapy with hematopoietic stem-cell rescue for multiple myeloma,” New England Journal of Medicine, vol. 348, no. 19, pp. 1875–1883, 2003. View at Publisher · View at Google Scholar · View at Scopus
  43. B. Barlogie, M. Attal, J. Crowley et al., “Long-term follow-up of autotransplantation trials for multiple myeloma: update of protocols conducted by the intergroupe francophone du myelome, southwest oncology group, and university of arkansas for medical sciences,” Journal of Clinical Oncology, vol. 28, no. 7, pp. 1209–1214, 2010. View at Publisher · View at Google Scholar · View at Scopus
  44. T. Philip, C. Guglielmi, A. Hagenbeek et al., “Autologous bone marrow transplantation as compared with salvage chemotherapy in relapses of chemotherapy-sensitive non-Hodgkin’s lymphoma,” New England Journal of Medicine, vol. 333, no. 23, pp. 1540–1545, 1995. View at Publisher · View at Google Scholar · View at Scopus
  45. A. Lashkari, W. A. Chow, F. Valdes et al., “Tandem high-dose chemotherapy followed by autologous transplantation in patients with locally advanced or metastatic sarcoma,” Anticancer Research, vol. 29, no. 8, pp. 3281–3288, 2009. View at Google Scholar
  46. F. Fagioli, M. Aglietta, A. Tienghi et al., “High-dose chemotherapy in the treatment of relapsed osteosarcoma: an Italian sarcoma group study,” Journal of Clinical Oncology, vol. 20, no. 8, pp. 2150–2156, 2002. View at Publisher · View at Google Scholar · View at Scopus
  47. U. Thiel, M. Schöniger, R. Haase et al., “Stem cell rescue after irradiation of multiple tumor sites combined with high-dose chemotherapy-high long-term survival in patients with advanced translocation positive pediatric sarcomas without bone marrow involvement,” Oncology Research and Treatment, vol. 39, p. 39, 2016. View at Google Scholar
  48. S. Ferrari, K. Sundby Hall, R. Luksch et al., “Nonmetastatic Ewing family tumors: high-dose chemotherapy with stem cell rescue in poor responder patients. results of the Italian Sarcoma Group/Scandinavian Sarcoma Group III protocol,” Annals of Oncology, vol. 22, no. 5, pp. 1221–1227, 2011. View at Publisher · View at Google Scholar · View at Scopus