A Longitudinal Study of Functional Outcomes in Patients with Limb Salvage Surgery for Soft Tissue Sarcoma

Table 2

Multivariate generalized estimating equation (GEE) analysis of predictors of functional outcome in MSTS and TESS.

Variables^a		MSTS			TESS
		Estimate	Standard error	value (95% CI)	Estimate	Standard error	value (95% CI)
Intercept		29.39	1.84	<0.0001 (25.78, 33.00)	101.81	7.20	<0.0001 (87.68, 115.94)
Time		0.05	0.01	0.001 (0.02, 0.08)	0.21	0.06	0.0004 (0.09, 0.33)
Age		−0.15	0.02	<0.0001 (−0.21, −0.10)	−0.54	0.10	<0.0001 (−0.75, −0.33)
Size		−0.01	0.08	0.86 (−0.18, 0.15)	−0.13	0.29	0.64 (−0.72, 0.45)
Stage group
Group 3	3	−2.86	1.83	0.11 (−6.46, 0.73)	−10.90	6.53	0.09 (−23.72, 1.90)
Group 2	2	−0.76	0.93	0.41 (−2.60, 1.06)	−4.50	3.40	0.18 (−11.18, 2.17)
Group 1	1	0	0		0	0
Anatomic location
Trunk	3	3.14	1.85	0.08 (−0.48, 6.77)	16.90	8.11	0.03 (1.00, 32.79)
Lower extremity	2	0.59	1.07	0.57 (−1.51, 2.71)	0.89	4.34	0.83 (−7.62, 9.41)
Upper extremity	1	0	0		0	0
Bone resection		−6.13	1.24	<0.0001 (−8.57, −3.68)	−19.28	4.38	<0.0001 (−27.89, −10.68)
Flap reconstruction		−0.11	1.00	0.91 (−2.08, 1.86)	2.34	3.94	0.55 (−5.38, 10.07)
Postoperative radiation		−1.14	1.26	0.36 (−3.62, 1.32)	−6.07	4.65	0.19 (−15.18, 3.04)

^aBone resection: 0 = no, 1 = yes; flap reconstruction: 0 = yes, 1 = no; CI: confidence interval.