Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation

Table 1

Changes in tumor biomarker expression following neoadjuvant chemoradiation in 12 “matched pair” large, deep, high-risk soft tissue sarcoma patients.

Marker	Pretreatment value		Posttreatment value		value
	Mean	SD	Mean	SD
ACIS Ki67
Percentage	15.91	19.78	7.65	7.30	0.0674
p53
Nuclear/cytoplasmic ratio	1.44	0.22	1.90	0.74	0.0469
ATM
Nuclear	8349.36	1920.35	7870.75	2114.36	0.4961
Cytoplasm	3811.69	2121.29	3116.21	1035.73	0.4258
Tumor mask	5289.39	2400.71	4412.80	1205.37	0.3594
PARP1
Nuclear	7042.80	1361.76	5533.59	1198.18	0.0313
Cytoplasm	3281.97	798.55	2293.63	471.64	0.0938
Tumor mask	4354.82	1092.11	3263.65	674.80	0.0625
ERCC1
Nuclear	9433.46	2247.20	8586.98	1658.74	0.3594
Cytoplasm	3046.29	1563.80	2197.19	917.54	0.0977
Tumor mask	5150.35	1600.28	4206.67	1335.08	0.0977
XPF
Nuclear	8772.27	1076.08	8880.11	2407.45	0.8457
Cytoplasm	4694.75	1556.58	4240.83	1254.75	0.3750
Tumor mask	6004.00	1598.71	5511.37	1619.80	0.4316
CAIX
Nuclear	3939.81	1273.12	2406.95	977.10	0.0234
Cytoplasm	3931.01	1699.38	2037.18	944.15	0.0391
Tumor mask	3972.93	1569.58	2124.05	926.91	0.0156
GLUT1
Nuclear	5389.90	2886.98	2937.34	1198.24	0.0781
Cytoplasm	4932.26	3106.79	2496.81	1116.73	0.1094
Tumor mask	5054.19	2998.35	2658.88	1128.22	0.0469
HIF-1α
Nuclear	6267.08	1603.95	5787.91	2241.58	0.4609
Cytoplasm	3857.75	1221.78	2978.52	1433.30	0.1484
Tumor mask	4582.47	1435.49	4009.57	2108.14	0.3828

SD: standard deviation; values are from the Wilcoxon signed-rank test on log-transformed values.