Correlation of High-Risk Soft Tissue Sarcoma Biomarker Expression Patterns with Outcome following Neoadjuvant Chemoradiation

Table 3

Correlation of posttreatment biopsy specimen tissue microarray biomarker expression with distant disease-free survival in 40 large, deep, high-risk soft tissue sarcoma patients treated with neoadjuvant chemoradiation.

Marker	HR (95% CI)	value
ACIS Ki67
Percentage	1.01 (0.60–1.69)	0.9691
p53
Nuclear/cytoplasmic ratio	4.16 (1.31–13.23)	0.0159
ATM
Nuclear	2.32 (0.35–15.59)	0.3859
Cytoplasm	1.93 (0.34–11.05)	0.4583
Tumor mask	1.37 (0.23–8.33)	0.7294
PARP1
Nuclear	1.37 (0.18–10.68)	0.7611
Cytoplasm	0.52 (0.12–2.34)	0.3971
Tumor mask	0.55 (0.13–2.43)	0.4313
ERCC1
Nuclear	0.78 (0.06–9.75)	0.8479
Cytoplasm	10.37 (0.11–1.22)	0.1038
Tumor mask	0.30 (0.09–0.98)	0.0455
XPF
Nuclear	0.01 (0.00–0.93)	0.0462
Cytoplasm	0.27 (0.03–2.43)	0.2415
Tumor mask	0.17 (0.02–1.69)	0.1304
CAIX
Nuclear	1.21 (0.47–3.12)	0.6885
Cytoplasm	1.32 (0.59–2.94)	0.5005
Tumor mask	1.31 (0.57–3.02)	0.5214
GLUT1
Nuclear	1.44 (0.50–4.18)	0.4984
Cytoplasm	1.24 (0.52–2.97)	0.6250
Tumor mask	1.27 (0.50–3.20)	0.6168
HIF-1α
Nuclear	0.59 (0.18–1.90)	0.3717
Cytoplasm	0.37 (0.12–1.17)	0.0913
Tumor mask	0.40 (0.14–1.17)	0.0951

HR: hazard ratio; CI: confidence interval.