Sarcoma

Research Article

Survival and Cost-Effectiveness of Trabectedin Compared to Ifosfamide Monotherapy in Advanced Soft Tissue Sarcoma Patients

Table 6

Nonparametric analysis of survival for L-sarcoma and non-L-sarcoma patients, univariate Kaplan–Meier analysis with median survival in months and logrank test, and multivariate Cox regression. The univariate hazard ratio for age per year increase was 0.99 for all tests.


Nonparametric survival	L-Sarcoma			Non-L-sarcoma
Univariate Kaplan–Meier	Median PFS	95% CI	value	Median PFS	95% CI	value

Progression-free survival
Age		0.96–1.02	0.395		0.97–1.01	0.460
Sex
(i) Female	3.19	0.00–6.62	0.621	2.89	1.76–4.03	0.931
(ii) Male	4.57	2.43–6.71		2.30	0.81–3.80
ECOG PS
(i) 0	3.68	1.08–6.28	0.602	3.22	0.00–6.45	0.022
(ii) 1 + 2	3.29	0.00–7.90		1.91	0.46–3.35
Drug received
(i) Trabectedin	5.19	3.31–7.07	0.074	2.04	1.52–2.55	0.819
(ii) Ifosfamide	2.63	0.43–4.83		3.25	2.33–4.18
Disease status
(i) Local	3.29	0.00–7.01	0.740	3.25	0.00–6.80	0.875
(ii) Metastatic	3.94	1.40–6.48		2.43	1.27–4.30
Multivariate Cox regression	HR	95% CI	value	HR	95% CI	value
(i) Drug received	0.60	0.33–1.07	0.086	1.35	0.67–2.74	0.403
(ii) ECOG PS	1.11	0.63–1.95	0.715	2.43	1.16–5.07	0.018

Univariate Kaplan–Meier	Median OS	95% CI	value	Median OS	95% CI	value

Overall survival
Age		0.96–1.02	0.498		0.97–1.01	0.273
Sex
(i) Female	8.35	2.66–14.0	0.071	9.17	5.63–12.7	0.796
(ii) Male	14.85	10.2–19.5		5.55	3.68–7.42
ECOG PS
(i) 0	13.41	7.57–19.2	0.033	13.77	7.72–19.8	0.008
(ii) 1 + 2	8.35	3.92–12.8		5.23	3.64–6.81
Drug received
(i) Trabectedin	11.80	7.78–15.8	0.184	5.98	0.70–11.3	0.903
(ii) Ifosfamide	8.22	0.00–21.2		8.94	5.97–11.9
Disease status
(i) Local	7.43	2.82–12.0	0.666	11.80	6.30–17.3	0.594
(ii) Metastatic	13.41	7.85–19.0		6.97	2.81–11.1
Multivariate Cox regression	HR	95% CI	value	HR	95% CI	value
(i) Drug received	0.66	0.37–1.18	0.162	1.73	0.85–3.50	0.128
(ii) ECOG PS	1.91	1.06–3.45	0.032	2.99	1.44–6.20	0.003

PFS: progression-free survival; OS: overall survival; 95% CI: 95% confidence interval; ECOG PS: ECOG performance score; HR: hazard ratio.