Sarcoma / 2019 / Article / Tab 6 / Research Article
Survival and Cost-Effectiveness of Trabectedin Compared to Ifosfamide Monotherapy in Advanced Soft Tissue Sarcoma Patients Table 6 Nonparametric analysis of survival for L-sarcoma and non-L-sarcoma patients, univariate Kaplan–Meier analysis with median survival in months and logrank test, and multivariate Cox regression. The univariate hazard ratio for age per year increase was 0.99 for all tests.
Nonparametric survival L-Sarcoma Non-L-sarcoma Univariate Kaplan–Meier Median PFS 95% CI valueMedian PFS 95% CI valueProgression-free survival Age 0.96–1.02 0.395 0.97–1.01 0.460 Sex (i) Female 3.19 0.00–6.62 0.621 2.89 1.76–4.03 0.931 (ii) Male 4.57 2.43–6.71 2.30 0.81–3.80 ECOG PS (i) 0 3.68 1.08–6.28 0.602 3.22 0.00–6.45 0.022 (ii) 1 + 2 3.29 0.00–7.90 1.91 0.46–3.35 Drug received (i) Trabectedin 5.19 3.31–7.07 0.074 2.04 1.52–2.55 0.819 (ii) Ifosfamide 2.63 0.43–4.83 3.25 2.33–4.18 Disease status (i) Local 3.29 0.00–7.01 0.740 3.25 0.00–6.80 0.875 (ii) Metastatic 3.94 1.40–6.48 2.43 1.27–4.30 Multivariate Cox regression HR 95% CI valueHR 95% CI value(i) Drug received 0.60 0.33–1.07 0.086 1.35 0.67–2.74 0.403 (ii) ECOG PS 1.11 0.63–1.95 0.715 2.43 1.16–5.07 0.018 Univariate Kaplan–Meier Median OS 95% CI valueMedian OS 95% CI valueOverall survival Age 0.96–1.02 0.498 0.97–1.01 0.273 Sex (i) Female 8.35 2.66–14.0 0.071 9.17 5.63–12.7 0.796 (ii) Male 14.85 10.2–19.5 5.55 3.68–7.42 ECOG PS (i) 0 13.41 7.57–19.2 0.033 13.77 7.72–19.8 0.008 (ii) 1 + 2 8.35 3.92–12.8 5.23 3.64–6.81 Drug received (i) Trabectedin 11.80 7.78–15.8 0.184 5.98 0.70–11.3 0.903 (ii) Ifosfamide 8.22 0.00–21.2 8.94 5.97–11.9 Disease status (i) Local 7.43 2.82–12.0 0.666 11.80 6.30–17.3 0.594 (ii) Metastatic 13.41 7.85–19.0 6.97 2.81–11.1 Multivariate Cox regression HR 95% CI valueHR 95% CI value(i) Drug received 0.66 0.37–1.18 0.162 1.73 0.85–3.50 0.128 (ii) ECOG PS 1.91 1.06–3.45 0.032 2.99 1.44–6.20 0.003
PFS: progression-free survival; OS: overall survival; 95% CI: 95% confidence interval; ECOG PS: ECOG performance score; HR: hazard ratio.