Research Article
Adjuvant Chemotherapy in Uterine Leiomyosarcoma: Trends and Factors Impacting Usage
Table 2
Multivariate predictors of chemotherapy receipt in nonmetastatic uterine LMS.
| Variable | OR | 95% CI | |
| Year of diagnosis | | | | Per year increase | 1.16 | 1.13–1.20 | <0.0001 |
| Age at diagnosis, y | | | | 18–39 | Ref | | | 40–49 | 0.93 | 0.67–1.31 | 0.6927 | 50–64 | 0.93 | 0.67–1.29 | 0.6537 | 65+ | 0.60 | 0.38–0.94 | 0.0264 |
| Race | | | | White | Ref | | | African American | 0.80 | 0.63–1.02 | 0.0727 | Other | 1.09 | 0.78–1.53 | 0.5965 |
| Hispanic | | | | Yes | 1.34 | 0.94–1.91 | 0.1112 | No | Ref | | |
| Comorbidities (Charlson/Deyo score) | | | | 0 | Ref | | | 1 | 0.93 | 0.73–1.18 | 0.5332 | 2 | 0.72 | 0.37–1.41 | 0.3381 |
| Insurance status | | | | Private | Ref | | | Medicare | 0.59 | 0.42–0.84 | 0.0030 | Medicaid | 1.06 | 0.77–1.48 | 0.7062 | None | 0.92 | 0.64–1.30 | 0.6265 | Other government | 2.42 | 1.04–5.61 | 0.0400 |
| Education (% no high school diploma) | | | | ≥21 | 0.68 | 0.48–0.97 | 0.0354 | 13–20.9 | 0.58 | 0.43–0.79 | 0.0005 | 7–12.9 | 0.86 | 0.68–1.09 | 0.2143 | <7 | Ref | | |
| Median household income ($) | | | | <38,000 | 1.49 | 1.04–2.13 | 0.0282 | 38,000–47,999 | 1.42 | 1.05–1.92 | 0.0239 | 48,000–62,999 | 1.37 | 1.07–1.75 | 0.0117 | >63,000 | Ref | | |
| Location of patient | | | | Large metropolitan | Ref | | | Small metropolitan | 0.92 | 0.73–1.15 | 0.4570 | Suburban | 1.00 | 0.73–1.39 | 0.9764 | Rural | 0.69 | 0.43–1.10 | 0.1146 |
| Hospital volume (cases per year) | | | | 0.09 | Ref | | | 0.18–0.27 | 1.00 | 0.62–1.61 | 0.9964 | 0.36–0.55 | 1.18 | 0.74–1.87 | 0.4912 | 0.64–7.27 | 1.27 | 0.82–1.98 | 0.2812 |
| Regional lymph nodes positive | | | | Yes | 3.83 | 1.81–8.09 | 0.0004 | No | Ref | | |
| Stage | | | | I | 0.32 | 0.25–0.41 | <0.0001 | II | 0.38 | 0.26–0.56 | <0.0001 | III | Ref | | |
| Hormone therapy | | | | Yes | 0.72 | 0.30–1.70 | 0.4473 | No | Ref | | |
| Radiation | | | | Yes | 1.45 | 1.17–1.79 | 0.0006 | No | Ref | | |
| Oophorectomy | | | | Yes | 0.92 | 0.72–1.19 | 0.5395 | No | Ref | | |
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