Research Article

Analysis of the CDK4/6 Cell Cycle Pathway in Leiomyosarcomas as a Potential Target for Inhibition by Palbociclib

Table 1

Recurrent high copy gains in leiomyosarcoma samples analysed by OncoScan. Cytoband location as well as DNA base range according to human genome assembly GRCh37 is annotated. The event frequency and lists of genes in the corresponding region are outlined.

CytobandRegionLength (bp)Frequency (%)GenesGene symbols

12q14.1chr12:58.125.215–58.255.15112993627.810AGAP2, TSPAN31, CDK4, MARCH9, CYP27B1, METTL1, METTL21B, TSFM, AVIL, CTDSP2
12q15chr12:68.593.003–69.052.98145997827.84IL26, IL22, MDM1, RAP1B
17p12chr17:12.000.608–12.087.6258701738.91MAP2K4
17p12chr17:12.105.562–12.579.45747389538.91MYOCD