Prognostic Factors in Dedifferentiated Chondrosarcoma: A Retrospective Analysis of a Large Series Treated at a Single Institution
Table 4
Significant prognostic factors for local relapse-free survival and metastasis-free survival in patients with nonmetastatic dedifferentiated chondrosarcoma by univariate and multivariate analyses.
Variable
Univariate
Multivariate
Median (months)
95% CI
HR
95% CI
Local relapse-free survival
61.7
Pathological fracture
0.008
NS
No
Not reached
Yes
11.0
0–25.5
Lymphovascular invasion
0.024
NS
No
Not reached
Yes
11.0
0–22.3
NA
61.7
0–142.4
Surgical margin
0.002
R0
Not reached
1.00
0.004
R1/R2
10.2
1.2–19.1
7.51
2.51–22.46
<0.001
No surgery
61.7
1.98
0.25–15.99
0.520
Metastasis-free survival
18.1
6.2–30.0
Pathological fracture
0.017
NS
No
31.6
0–82.3
Yes
6.4
3.1–9.7
Size of dedifferentiated component
0.017
0.044
Microscopic
Not reached
1.00
Macroscopic
9.0
6.4–11.6
7.78
1.06–57.17
CI, confidence interval; HR, hazard ratio; NS, not significant.
