Review Article
Patient and Tumour Characteristics of Adult Head and Neck Soft Tissue Sarcomas: A Systematic Review and Meta-Analysis
Table 1
Patient data and characteristics.
| | Mahmoud et al. [7] | Andrä et al. [8] | González-González et al. [9] | Vitzthum et al. [10] | Tejani et al. [6] | Penel et al. [11] | Sidappa and Krishnamurthy [12] | Park et al. [13] | Total |
| Country | USA | Germany | Mexico | USA | USA | France | India | Korea | N | % | Years | 2004–2013 | 2003–2012 | 2004–2009 | 1998–2012 | 1999–2009 | 1997–2002 | 1996–2005 | 1995–2012 | | | | N | % | N | % | N | % | N | % | N | % | N | % | N | % | N | % | | | Cases | 788 | | 26 | | 51 | | 48 | | 30 | | 28 | | 27 | | 122 | | 1120 | | Male | 539 | 68 | 18 | 69 | 31 | 61 | 34 | 71 | 20 | 67 | 15 | 54 | 17 | 63 | 65 | 53 | 739 | 66 | Median age | 63 | | 64 | | 43.1 | | 68.5 | | 50 | | 45.7 | | 35 | | 46 | | — | | <50 | 181 | 23a | — | | 34 | 67 | — | | 12 | 40 | 11 | 39 | — | | — | | 238 | 27 | >50 | 607 | 77 | — | | 17 | 33b | — | | 18 | 60 | 17 | 61b | — | | — | | 659 | 73 | Tumour size | | | | | | | | | | | | | | | | | | | <5 cm | 443 | 56 | — | | 15 | 29c | 33 | 69c | 13 | 43 | — | | 17 | 63 | 86 | 70c | 607 | 57 | >5 cm | 345 | 44d | — | | 36 | 71 | 15 | 31 | 11 | 37 | — | | 10 | 37 | 36 | 30 | 453 | 43 | Mean tumour size (cm) | 4.5e | | 4.6e | | — | | — | | — | | 2.7 | | 4.8 | | | | — | | Grade (FNCLCC) | | | | | | | | | | | | | | | | | | | High/G3 | 788 | 100 | 17 | 65 | 30 | 59 | 28 | 58f | 23 | 77 | 16 | 57 | 21 | 78g | 22 | 18 | 945 | 84 | Intermediate/G2 | 0 | | 8 | 31 | 10 | 20 | 0 | | 3 | 10 | 8 | 29 | 0 | | 53 | 43 | 82 | 7 | Low/G1 | 0 | | 1 | 4 | 11 | 22 | 6 | 13 | 2 | 7 | 2 | 7 | 6 | 22 | 30 | 25 | 58 | 5 | Unspecified/unknown | 0 | | 0 | | 0 | | 14 | 29 | 2 | 7 | 2 | 7 | 0 | | 17 | 14 | 35 | 3 | T stage | | | | | | | | | | | | | | | | | | | 0 | — | | — | | — | | — | | — | | — | | — | | — | | — | | 1 | — | | 14 | 54 | 13 | 25 | — | | 12 | 40 | — | | — | | — | | 39 | 23 | 2 | — | | 12 | 46 | 38 | 75 | — | | 18 | 60 | — | | — | | — | | 68 | 40 | 3 | — | | — | | — | | — | | — | | — | | — | | — | | — | | 4 | — | | — | | — | | — | | — | | — | | — | | — | | — | | Surgical margins† | | | | | | | | | | | | | | | | | | | R0 | 497 | 63 | 10 | 39 | 35 | 69 | 41 | 85 | 17 | 57 | — | | 20 | 74 | 76 | 62 | 696 | 60 | R1 | 111 | 14 | 6 | 23 | 4 | 8 | — | | 7 | 23 | — | | 6 | 22h | 20 | 16 | 154 | 13 | R2 | 180 | 23 | 5 | 19 | 13 | 25 | 3 | 6 | — | | — | | — | | 7 | 6 | 208 | 18 | Unspecified/unknown | — | | 5 | 19 | — | | 4 | 8 | — | | — | | — | | — | | 9 | 1 | 5-year OS | — | | | 82 | — | | | 83 | | 46 | — | | 68 | | 75 | | — | | 5-year DFS | — | | — | | — | | | 63 | | 35 | — | | 65 | | — | | — | | Median follow-up (months) | 45 | | 39 | | 23.8 | | 57.6 | | — | | 27 | | 59 | | 72 | | — | |
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a≤50, b≥50, c≤5, d≥5, emedian, fgrade 2 + 3, ggrading system not specified in the article, and hR1 + R2. †R0 = negative surgical margins/clear margins, R1 = microscopic positive surgical margins/microscopic involved margins, and R2 = macroscopic positive margins/macroscopic involved margins.
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