Time to Treatment Initiation and Survival in Adult Localized High-Grade Bone Sarcoma

Table 4

Multivariate analysis of factors associated with survival.

Factors		Hazard ratio	95% hazard ratio CI		values
Time to treatments, days	TTI—a 10-day increase from day 14	1.00	0.98	1.02	0.72
	TTI—a 10-day increase from day 30	1.00	0.98	1.02	0.72
	TTI—a 10-day increase from day 60	1.00	0.98	1.02	0.72
	TTI—a 10-day increase from day 90	1.00	0.98	1.02	0.72
	TTI—a 10-day increase from day 150	1.00	0.98	1.02	0.72
Age group, years	31–50 vs. 18–30	1.16	0.88	1.51	0.29
	51–70 vs. 18–30	1.66	1.17	2.34	0.004
	71+ vs. 18–30	2.89	1.95	4.28	<0.001
Sex	Female vs. male	0.94	0.82	1.07	0.33
Race	Black vs. white	0.94	0.75	1.17	0.59
	Other/unknown vs. white	0.98	0.73	1.31	0.88
Charlson/Deyo score	1 vs. 0	1.11	0.90	1.36	0.34
	≥2 vs. 0	2.02	1.45	2.81	<0.001
Income	$38,000–$47,999 vs. <$38,000	1.08	0.88	1.33	0.45
	$48,000–$62,999 vs. <$38,000	1.03	0.84	1.27	0.75
	$63,000+ vs. <$38,000	1.04	0.84	1.29	0.70
Insurance	Private insurance vs. uninsured	0.65	0.49	0.87	0.004
	Medicaid vs. uninsured	0.85	0.61	1.18	0.33
	Medicare vs. uninsured	0.71	0.51	0.99	0.043
	Other/unknown vs. uninsured	0.75	0.51	1.10	0.15
Facility type	Comprehensive community cancer program vs. community cancer program	0.89	0.58	1.39	0.62
	Academic center vs. community cancer program	0.64	0.41	0.98	0.039
	Integrated network cancer program vs. community cancer program	0.99	0.58	1.68	0.97
	Other/unknown vs. community cancer program	0.50	0.30	0.82	0.006
Distance from facility	21–50 miles vs. <21 miles	1.17	0.98	1.39	0.088
	51–100 miles vs. <21 miles	1.30	1.06	1.59	0.012
	>100 miles vs. <21 miles	1.08	0.88	1.33	0.44
Transition in care	Yes vs. No	0.90	0.78	1.04	0.14
Year of diagnosis	2005 vs. 2004	1.06	0.79	1.41	0.71
	2006 vs. 2004	0.84	0.63	1.13	0.26
	2007 vs. 2004	1.18	0.88	1.58	0.27
	2008 vs. 2004	0.84	0.62	1.13	0.25
	2009 vs. 2004	0.90	0.67	1.21	0.48
	2010 vs. 2004	1.00	0.74	1.35	0.99
	2011 vs. 2004	1.22	0.90	1.65	0.19
	2012 vs. 2004	1.06	0.76	1.47	0.73
First-line treatment modality	Radiation vs. surgery	1.81	1.35	2.42	<0.001
	Systemic vs. surgery	1.17	0.99	1.39	0.06
	Multimodal vs. surgery	0.60	0.24	1.49	0.27
Histology	Chondrosarcoma vs. osteosarcoma	0.75	0.62	0.90	0.002
	Ewing’s sarcoma vs. osteosarcoma	0.82	0.62	1.09	0.17
	Chordoma vs. osteosarcoma	0.27	0.10	0.73	0.01
	Other vs. osteosarcoma	0.75	0.59	0.96	0.022
Primary tumor site	Lower extremity vs. upper extremity	0.92	0.75	1.13	0.42
	Pelvis vs. upper extremity	1.58	1.26	1.99	<0.001
	Other vs. upper extremity	1.05	0.83	1.32	0.70
Tumor size	>8.0 cm vs. ≤8.0 cm	1.52	1.32	1.76	<0.001
Grade	Undifferentiated vs. poorly differentiated	1.07	0.94	1.23	0.31
Clinical staging	Stage II vs. stage I	0.96	0.77	1.20	0.72
	Stage III vs. stage I	0.97	0.69	1.38	0.87

TTI: time to treatment initiation; CI: confidence interval.