Deep Functional and Molecular Characterization of a High-Risk Undifferentiated Pleomorphic Sarcoma

Figure 2

Circos plot of PCB-209 RNA sequencing and whole genome sequencing data. The outermost data circle represents log₂-scaled gene expression (green represents negative, red represents positive) for genes with identified mutations or copy number variations. The middle circle represents genes with identified mutations or indels (black) or lack thereof (white). The innermost circle represents copy number variations (pink is amplification, light blue is deletion, and white is no variation). Genes which carry both mutations and amplifications (TNS3, BRINP1, RABEP1, and CDH4) are written in blue around the circle, as are genes relevant to in vivo studies (HDAC1, ALK, GL1, HDAC3, FLT4, PSMB8, HDAC2, JAK2, PSMB5, MAP2K1, PRKCA, BCL2, MAP2K2, AKT2, BCL2L1, and MAPK1).