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| Study ID | Study title | Study design | Hypofractionated preoperative dose/fractionation | Status | Location | Institution |
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| NCT04425967 | Short course of preoperative radiotherapy in head and neck, trunk, and extremity soft-tissue sarcomas (SCOPES) | Randomized phase II study | 14 Gy × 3 | Recruiting | The Netherlands | Leiden University Medical Center |
| NCT02634710 | Hypofractionated preoperative radiation therapy for soft-tissue sarcomas of the extremity and chest wall | Phase II study | 7 Gy × 5 | Active, not recruiting | United States | Medical College of Wisconsin |
| NCT03972930 | Hypofractionated radiotherapy for soft-tissue sarcomas | Phase II study | Variable | Recruiting | United States | Medical College of Wisconsin |
| NCT04330456 | Combined treatment of patients with soft-tissue sarcoma including preoperative stereotactic radiation therapy and postoperative conformal radiation therapy | Phase II study | 5 Gy × 5 | Recruiting | Russia | N.N. Petrov National Medical Research Center of Oncology |
| NCT02812654 | Ifosfamide, doxorubicin, and hypofractionated radiotherapy in neoadjuvant sarcoma treatment | Phase II study | 5 Gy × 5 | Unknown | Brazil | A.C. Camargo Cancer Center |
| NCT03989596 | Hypofractionated radiotherapy with hyperthermia in unresectable or marginally resectable soft-tissue sarcomas (SINDIR) | Phase II study | 3.25 Gy × 10 | Active, not recruiting | Poland | Maria Sklodowska-Curie Institute |
| NCT03819985 | Shorter-course, hypofractionated presurgery radiation therapy in treating patients with localized, resectable soft-tissue sarcoma of the extremity of the superficial trunk | Phase II study | 2.85 Gy × 15 | Recruiting | United States | MD Anderson Cancer Center |
| NCT03651375 | Hypofractionated radiotherapy with sequential chemotherapy in marginally resectable soft-tissue sarcomas of the extremities or trunk wall (UN-RESARC) | Phase II study | 5 Gy × 5 | Active, not recruiting | Poland | Maria Sklodowska-Curie Institute |
| NCT03816475 | Hypofractionated radiotherapy in locally advanced myxoid liposarcomas of the extremities or trunk wall (LIPO-MYX trial) (LIPO-MYX) | Phase II study | 5 Gy × 5 | Active, not recruiting | Poland | Maria Sklodowska-Curie Institute |
| NCT02701153 | Phase II study of 5-day hypofractionated preoperative radiation therapy for soft-tissue sarcomas: expansion cohort | Phase II study | 5-6 Gy × 5 | Recruiting | United States | UCLA |
| NCT04562480 | Hypofractionated radiation therapy before surgery for the treatment of localized, resectable soft-tissue sarcoma of the extremity and superficial trunk | Phase II study | 2.85 Gy × 15 | Recruiting | United States | Mayo Clinic |
| NCT04617327 | Preoperative RadiothErapy for soft-tissue SarcOmas (PRESTO) | Phase I/II study | 7 Gy × 5 | Recruiting | Canada | McGill University |
| NCT00822848 | Sorafenib, epirubicin, ifosfamide, and radiation therapy followed by surgery in treating patients with high-risk stage II or stage III soft-tissue sarcoma | Phase I study | 3.5 Gy × 8 | Completed | United States | Oregon Health Sciences University |
| NCT03989596 | Hypofractionated radiotherapy with hyperthermia in unresectable or marginally resectable soft-tissue sarcomas (SINDIR) | Phase II study | 3.25 Gy × 10 | Active, not recruiting | Poland | Maria Sklodowska-Curie Institute |
| NCT04398095 | Radiotherapy with hyperthermia in recurrent and radiation-induced sarcomas (HOT) | Phase II study | 3 Gy × 12 | Recruiting | Poland | Maria Sklodowska-Curie Institute |
| NCT04506008 | Hypofractionated radiotherapy followed by immediate surgical resection in the treatment of soft-tissue sarcomas | Phase II study | Not listed | Recruiting | United States | Vanderbilt University |
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