Sarcoma / 2021 / Article / Tab 1

Research Article

Evaluating Thresholds to Adopt Hypofractionated Preoperative Radiotherapy as Standard of Care in Sarcoma

Table 1

Ongoing preoperative hypofractionated trials.

Study IDStudy titleStudy designHypofractionated preoperative dose/fractionationStatusLocationInstitution

NCT04425967Short course of preoperative radiotherapy in head and neck, trunk, and extremity soft-tissue sarcomas (SCOPES)Randomized phase II study14 Gy × 3RecruitingThe NetherlandsLeiden University Medical Center
NCT02634710Hypofractionated preoperative radiation therapy for soft-tissue sarcomas of the extremity and chest wallPhase II study7 Gy × 5Active, not recruitingUnited StatesMedical College of Wisconsin
NCT03972930Hypofractionated radiotherapy for soft-tissue sarcomasPhase II studyVariableRecruitingUnited StatesMedical College of Wisconsin
NCT04330456Combined treatment of patients with soft-tissue sarcoma including preoperative stereotactic radiation therapy and postoperative conformal radiation therapyPhase II study5 Gy × 5RecruitingRussiaN.N. Petrov National Medical Research Center of Oncology
NCT02812654Ifosfamide, doxorubicin, and hypofractionated radiotherapy in neoadjuvant sarcoma treatmentPhase II study5 Gy × 5UnknownBrazilA.C. Camargo Cancer Center
NCT03989596Hypofractionated radiotherapy with hyperthermia in unresectable or marginally resectable soft-tissue sarcomas (SINDIR)Phase II study3.25 Gy × 10Active, not recruitingPolandMaria Sklodowska-Curie Institute
NCT03819985Shorter-course, hypofractionated presurgery radiation therapy in treating patients with localized, resectable soft-tissue sarcoma of the extremity of the superficial trunkPhase II study2.85 Gy × 15RecruitingUnited StatesMD Anderson Cancer Center
NCT03651375Hypofractionated radiotherapy with sequential chemotherapy in marginally resectable soft-tissue sarcomas of the extremities or trunk wall (UN-RESARC)Phase II study5 Gy × 5Active, not recruitingPolandMaria Sklodowska-Curie Institute
NCT03816475Hypofractionated radiotherapy in locally advanced myxoid liposarcomas of the extremities or trunk wall (LIPO-MYX trial) (LIPO-MYX)Phase II study5 Gy × 5Active, not recruitingPolandMaria Sklodowska-Curie Institute
NCT02701153Phase II study of 5-day hypofractionated preoperative radiation therapy for soft-tissue sarcomas: expansion cohortPhase II study5-6 Gy × 5RecruitingUnited StatesUCLA
NCT04562480Hypofractionated radiation therapy before surgery for the treatment of localized, resectable soft-tissue sarcoma of the extremity and superficial trunkPhase II study2.85 Gy × 15RecruitingUnited StatesMayo Clinic
NCT04617327Preoperative RadiothErapy for soft-tissue SarcOmas (PRESTO)Phase I/II study7 Gy × 5RecruitingCanadaMcGill University
NCT00822848Sorafenib, epirubicin, ifosfamide, and radiation therapy followed by surgery in treating patients with high-risk stage II or stage III soft-tissue sarcomaPhase I study3.5 Gy × 8CompletedUnited StatesOregon Health Sciences University
NCT03989596Hypofractionated radiotherapy with hyperthermia in unresectable or marginally resectable soft-tissue sarcomas (SINDIR)Phase II study3.25 Gy × 10Active, not recruitingPolandMaria Sklodowska-Curie Institute
NCT04398095Radiotherapy with hyperthermia in recurrent and radiation-induced sarcomas (HOT)Phase II study3 Gy × 12RecruitingPolandMaria Sklodowska-Curie Institute
NCT04506008Hypofractionated radiotherapy followed by immediate surgical resection in the treatment of soft-tissue sarcomasPhase II studyNot listedRecruitingUnited StatesVanderbilt University

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