Patterns of Perioperative Treatment and Survival of Localized, Resected, Intermediate- or High-Grade Soft Tissue Sarcoma: A 2000–2017 Netherlands Cancer Registry Database Analysis

Table 4

Estimated odds ratio (OR) along with 95% confidence interval (CI) estimated from univariable logistic regression models on the association between patient and tumor factors and the chance of receiving perioperative radiotherapy for grade II and III resected soft tissue sarcoma in the Netherlands between 2000 and 2017.

Factor	OR	95% CI	value
Age (continuous)	0.982	0.979–0.986	<0.001
Sex			0.030
Female sex (ref.)	—	—
Male sex	1.132	1.012–1.266
Location			<0.001
Lower extremity (ref.)	—	—
Upper extremity	0.769	0.645–0.916
Head & neck	0.231	0.192–0.278
Trunk	0.376	0.328–0.431
Heart/mediastinum/pleura	0.255	0.132–0.494
Subtype			<0.001
UPS (ref.)	—	—
Myxofibrosarcoma	2.346	1.878–2.929
Leiomyosarcoma	0.754	0.615–0.926
Angiosarcoma	0.283	0.216–0.371
MPNST	1.062	0.823–1.370
Synovial sarcoma	1.866	1.415–2.462
MLS	2.665	2.087–3.404
Pleomorphic liposarcoma	1.827	1.249–2.671
Dedifferentiated liposarcoma	0.857	0.638–1.151
Liposarcomas NOS	1.370	0.846–2.219
Rest category	0.885	0.734–1.068
Grade			0.009
Intermediate grade II (ref.)	—	—
High grade III	1.170	1.040–1.315
Tumor size			<0.001
≤5 cm (ref.)	—	—
>5 cm	2.418	2.122–2.756
Tumor depth			<0.001
Superficial depth (ref.)	—	—
Deep depth	1.660	1.465–1.880

Abbreviations: OR=odds ratio, CI=confidence interval, ref. = reference, UPS = undifferentiated pleomorphic sarcoma, MPNST = malignant peripheral nerve sheath tumor, MLS = myxoid liposarcoma, NOS = not otherwise specified. .