Sarcoma / 2021 / Article / Tab 6 / Research Article
Patterns of Perioperative Treatment and Survival of Localized, Resected, Intermediate- or High-Grade Soft Tissue Sarcoma: A 2000–2017 Netherlands Cancer Registry Database Analysis Table 6 Estimated hazard ratio (HR) along with 95% confidence interval from a multivariable Cox regression model on the association between prognostic factors and overall survival for grades II and III resected STS in the Netherlands between 2000 and 2017.
Factor HR 95% CI Age Young (ref.) — — — Middle 1.651 1.471–1.854 <0.001 Old 3.323 2.952–3.740 <0.001 Sex Female sex (ref.) — — — Male sex 1.097 1.009–1.193 0.030 Year of diagnosis 2009–2017 (ref.) — — — 2000–2008 1.169 1.072–1.274 <0.001 Location Lower extremity (ref.) — — — Upper extremity 0.922 0.807–1.054 0.234 Head and neck 1.228 1.074–1.404 0.003 Trunk 1.183 1.066–1.314 0.002 Heart/mediastinum/pleura 2.177 1.464–3.235 <0.001 Subtype UPS (ref.) — — — Myxofibrosarcoma 0.885 0.747–1.048 0.157 Leiomyosarcoma 1.228 1.060–1.422 0.006 Angiosarcoma 1.631 1.338–1.988 <0.001 MPNST 1.328 1.079–1.635 0.008 Synovial sarcoma 0.986 0.797–1.219 0.895 MLS 0.613 0.480–0.783 <0.001 Pleomorphic liposarcoma 0.813 0.623–1.060 0.126 Dedifferentiated liposarcoma 0.805 0.652–0.995 0.045 Liposarcoma NOS 0.864 0.630–1.185 0.364 Rest category 0.968 0.839–1.116 0.651 Grade Intermediate grade II (ref.) — — — High grade III 1.417 1.264–1.589 <0.001 Tumor size ≤5 cm (ref.) — — — >5 cm 1.631 1.451–1.833 <0.001 Tumor depth Superficial depth (ref.) — — — Deep depth 1.234 1.122–1.356 <0.001 Perioperative RT No (ref.) — — — Yes 0.810 0.741–0.886 <0.001 Perioperative chemotherapy No (ref.) — — — Yes 1.137 0.936–1.381 0.196 Surgical margins R0 margins (ref.) — — — R1/R2 margins 1.492 1.327–1.677 <0.001
Abbreviations: HR=hazard ratio, CI=confidence interval, ref. = reference, UPS = undifferentiated pleomorphic sarcoma, MPNST = malignant peripheral nerve sheath tumor, MLS = myxoid liposarcoma, NOS = not otherwise specified, RT = radiotherapy.
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