Adjuvant Radiation after Primary Resection of Atypical Lipomatous Tumors of the Extremity Reduces Local Recurrence but Increases Complications: A Multicenter Evaluation

Table 5

Univariate and multivariate logistic regression analyses of patient characteristics with complication requiring medical or surgical management.

	Univariate analysis		Multivariate analysis
	OR (95% CI)	-value	OR (95% CI)	-value
Age (10-year intervals)	1.21 (0.90–1.61)	0.20	—	—
Sex
Male	1.58 (0.79–3.15)	0.19	—	—
Female	Ref
Tumor location
Upper extremity	0.21 (0.03–1.70)	0.07	—	—
Lower extremity	Ref
Tumor size (5-cm intervals)	1.35 (1.07–1.69)	0.009	1.31 (1.03–1.66)	0.03
MDM2 status
Positive	Ref
Unavailable	1.25 (0.63–2.47)	0.53	—	—
Tumor depth
Deep	Ref
Superficial	0.60 (0.12–2.89)	0.50	—	—
Tumor NVI
Yes	1.14 (0.57–2.30)	0.70	—	—
No	Ref
Surgical resection margins
R0/R1	Ref
R2	1	—	—	—
Treatment center
Center 1	Ref
Center 2	0.14 (0.04–0.47)	<0.001	—	—
Radiation
Yes	5.17 (2.15–12.46)	<0.001	4.77 (1.96–11.62)	<0.001
No	Ref
Radiation dose (10 Gy intervals)	1.20 (1.07–1.35)	0.002	—	—

OR, odds ratio; CI, confidence interval; ref, reference group; NVI, neurovascular involvement; Gy, gray.