Targeting the FAK-Src Complex in Desmoplastic Small Round Cell Tumors, Ewing Sarcoma, and Rhabdomyosarcoma
Table 1
Patient characteristics of ES, DSRCT, ARMS, and ERMS tumor tissue.
Tumor type
Characteristics
N (%)
DSRCT (n = 13)
Gender
Male
9 (69)
Female
4 (31)
Age at diagnosis
<18 y ≥18 y
4 (31) 9 (69)
Translocation
EWSR1-WT1
13 (100)
Metastases
Yes
10 (77)
Unknown
3 (23)
Initial metastases
Yes
10 (100)a
Sample source
Primary tumor
9 (69)
Resection (post-treatment)
4 (31)
ES (n = 68)
Gender
Male
31 (46)
Female
37 (54)
Age at diagnosis
<18 y
44 (65)
≥18 y
24 (35)
Translocation
EWSR1-FLI1
56 (82)
EWSR1-ERG
9 (13)
Positive (not specified)
3 (5)
Metastases
Yes
19 (28)
No
30 (44)
Unknown
19 (28)
Initial metastases
Yes
7 (37)a
Sample source
Primary tumor
33 (49)
Resection (post-treatment)
18 (26)
Metastasis
11 (16)
Local recurrence
4 (6)
Other
2 (3)
ARMS (n = 21)
Gender
Male
13 (62)
Female
8 (38)
Age at diagnosis
<18 y
15 (71)
≥18 y
6 (29)
Translocation
PAX3-FOXO1
10 (48)
PAX7-FOXO1
5 (24)
Positive (not specified)
6 (28)
Metastases
Yes
9 (43)
No
3 (14)
Unknown
9 (43)
Initial metastases
Yes
3 (33)a
Sample source
Primary tumor
7 (33)
Lymph node
7 (33)
Metastasis
1 (5)
Resection (post-treatment)
3 (14)
Local recurrence
3 (14)
ERMS (n = 39)
Gender
Male
35 (90)
Female
4 (10)
Age at diagnosis
<18 y
35 (90)
≥18y
4 (10)
Metastases
Yes
2 (5)
No
33 (85)
Unknown
4 (10)
Initial metastases
Yes
1 (50)a
Sample source
Primary tumor
31 (80)
Resection (post-treatment)
6 (15)
Metastasis
2 (5)
DSRCT: desmoplastic small round cell tumor; ES: Ewing sarcoma; ARMS: alveolar rhabdomyosarcoma; ERMS: embryonal rhabdomyosarcoma; N: number of patients; a percentage calculation: (total with initial metastases/total with metastases) 100%.
