Prognostic Significance of Bone Metastasis in Soft Tissue Sarcoma Patients Receiving Palliative Systemic Therapy: An Explorative, Retrospective Pooled Analysis of the EORTC-Soft Tissue and Bone Sarcoma Group (STBSG) Database
Table 3
Cox model for the adjusted effect of bone metastasis on OS per line of treatment stratified by study.
Parameter
Levels
Hazard ratio for first-line treatment (95% CI)
value (first-line)
Hazard ratio for second-line or higher treatment (95% CI)
value (second line or higher)
Metastasis in bone
Absent
1.00
0.061
1.00
0.533
Present
1.33 (0.99, 1.78)
1.11 (0.81, 1.52)
Histology type (local review)
Angiosarcoma
1.00
1.00
Leiomyosarcoma
0.68 (0.39, 1.18)
1.03 (0.40, 2.65)
Liposarcoma (all subtypes)
0.65 (0.35, 1.20)
3.05 (1.10, 8.48)
Others
0.89 (0.52, 1.54)
2.00 (0.79, 5.04)
Synovial sarcoma
0.95 (0.52, 1.73)
2.35 (0.91, 6.04)
Age category
Less than 40
1.00
1.00
40 to 50
1.05 (0.79, 1.41)
1.25 (0.86, 1.81)
50 to 70
1.24 (0.93, 1.66)
1.42 (1.05, 1.91)
Older than 70
1.25 (0.61, 2.55)
1.88 (1.21, 2.93)
Gender
Male
1.00
1.00
Female
0.95 (0.77, 1.17)
0.89 (0.70, 1.13)
Tumour grade
Low/intermediate
1.00
1.00
High
1.38 (1.11, 1.71)
1.39 (1.11, 1.75)
Metastasis in liver
Absent
1.00
1.00
Present
1.47 (1.11, 1.95)
1.04 (0.79, 1.36)
Metastasis in lymph nodes
Absent
1.00
1.00
Present
1.25 (0.99, 1.56)
1.34 (1.02, 1.77)
Metastasis in lung
Absent
1.00
1.00
Present
1.25 (0.98, 1.59)
1.14 (0.88, 1.49)
Metastasis in other sites
Absent
1.00
1.00
Present
1.53 (1.20, 1.95)
1.36 (1.07, 1.73)
Metastasis in soft-tissue (primary or other soft-tissue invasive)
Absent
1.00
1.00
Present
1.09 (0.86, 1.38)
1.25 (0.98, 1.60)
Site of primary tumour
Extremities
1.00
1.00
Abdomen
1.27 (0.90, 1.78)
1.10 (0.78, 1.54)
Others
1.01 (0.73, 1.39)
1.08 (0.72, 1.62)
Thorax
1.00 (0.68, 1.47)
1.29 (0.90, 1.85)
Visceral
1.21 (0.88, 1.65)
1.25 (0.89, 1.77)
Performance status
0
1.00
1.00
1
1.67 (1.36, 2.05)
1.70 (1.34, 2.17)
Time between histological diagnosis and registration/randomisation
Less than a year
1.00
1.00
1-2 years
0.78 (0.58, 1.06)
0.94 (0.68, 1.30)
More than 2 years
0.61 (0.47, 0.79)
0.60 (0.44, 0.80)
Note that 977 (94.5%) of the patients were analysed due to some missing values.
