Sarcoma

The Molecular Basis of Sarcoma


Publishing date
15 Mar 2011
Status
Published
Submission deadline
15 Sep 2010

Guest Editors

1Center for Children's Cancer Research, Huntsman Cancer Institute, 2000 Circle of Hope, Salt Lake City, UT 84112, USA

2Children's Cancer Research Institute, St. Anna Kinderspital, Vienna, Austria

3Nationwide Children's Hospital in Columbus, Ohio, OH, USA


The Molecular Basis of Sarcoma

Description

The sarcoma field is at a crossroads. There have been incredible advances in the identification and characterization of key genetic events associated with sarcoma development. For example, many chromosomal translocation breakpoints have been cloned, and the fusion proteins associated with those breakpoints have been subjected to rigorous molecular analysis. Similarly, there has been an explosion of molecularly targeted agents available for the treatment of patients with cancer. In cases where these targeted agents inhibit a key abnormality in sarcoma, such as activated KIT in gastrointestinal stromal tumor, they have been quite successful. Unfortunately, examples of such success are still limited. Many investigators in the field have hoped that deeper understanding of the molecular basis of sarcoma may lead to new therapeutic opportunities for this varied set of diseases.

The focus of this special issue will be to highlight recent advances in the understanding of the molecular basis of sarcoma, with a goal of providing a strong foundation for investigators to consider these data during the development of new therapeutic approaches. Reviews that summarize topics in particular sarcomas, or that span multiple sarcoma subtypes, will be welcome. Furthermore, reviews that focus on current research advances are particularly encouraged. Main topics include, but are not limited to:

  • Fusion proteins and their function in sarcoma
  • Recurrent activating and inactivating mutations in sarcoma
  • The genetic basis of sarcoma, even if the key mutation has not yet been identified
  • Abnormalities in signaling pathways in sarcoma
  • Abnormalities in cell cycle, differentiation, and/or cell death in sarcoma
  • Advances in animal models that provide new understanding in sarcoma development
  • Transcriptional effects, micro-RNAs, and other noncoding RNAs in sarcoma
  • The role of epigenetic alterations in sarcoma
  • Mechanisms of drug resistance in sarcoma

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/srcm/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 864130
  • - Editorial

The Molecular Basis of Sarcoma

Stephen L. Lessnick | Heinrich Kovar | Peter Houghton
  • Special Issue
  • - Volume 2011
  • - Article ID 218483
  • - Research Article

Tyrosine Phosphorylation in the C-Terminal Nuclear Localization and Retention Signal (C-NLS) of the EWS Protein

Ruzanna P. Leemann-Zakaryan | Steffen Pahlich | ... | Heinz Gehring
  • Special Issue
  • - Volume 2011
  • - Article ID 638403
  • - Research Article

Delineation of Chondroid Lipoma: An Immunohistochemical and Molecular Biological Analysis

Ronald S. A. de Vreeze | Frits van Coevorden | ... | Daphne de Jong
  • Special Issue
  • - Volume 2011
  • - Article ID 260757
  • - Review Article

The Role of Mirk Kinase in Sarcomas

Eileen Friedman
  • Special Issue
  • - Volume 2011
  • - Article ID 959248
  • - Review Article

The Molecular Pathogenesis of Osteosarcoma: A Review

Matthew L. Broadhead | Jonathan C. M. Clark | ... | Peter F. M. Choong
  • Special Issue
  • - Volume 2011
  • - Article ID 959132
  • - Review Article

Advances in Molecular Characterization and Targeted Therapy in Dermatofibrosarcoma Protuberans

Piotr Rutkowski | Agnieszka Wozniak | Tomasz Switaj
  • Special Issue
  • - Volume 2011
  • - Article ID 598218
  • - Research Article

Human Chondrosarcoma Cells Acquire an Epithelial-Like Gene Expression Pattern via an Epigenetic Switch: Evidence for Mesenchymal-Epithelial Transition during Sarcomagenesis

Matthew P. Fitzgerald | Francoise Gourronc | ... | Frederick E. Domann
  • Special Issue
  • - Volume 2011
  • - Article ID 362173
  • - Review Article

Copy Number Alterations and Methylation in Ewing's Sarcoma

Mona S. Jahromi | Kevin B. Jones | Joshua D. Schiffman
  • Special Issue
  • - Volume 2011
  • - Article ID 378957
  • - Review Article

Spinal Chondrosarcoma: A Review

Pavlos Katonis | Kalliopi Alpantaki | ... | Apostolos Karantanas
  • Special Issue
  • - Volume 2011
  • - Article ID 548151
  • - Review Article

Using Epidemiology and Genomics to Understand Osteosarcoma Etiology

Sharon A. Savage | Lisa Mirabello
Sarcoma
 Journal metrics
Acceptance rate55%
Submission to final decision96 days
Acceptance to publication46 days
CiteScore2.340
Impact Factor-
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