Soft Tissue Sarcoma: New Paradigms in Care

Publishing date
07 Dec 2012
Submission deadline
20 Jul 2012

1St. Vincent's Hospital, University of Melbourne, Fitzroy 3065, Australia

2Royal Orthopaedic Hospital, Stanmore, UK

3Ludwig Institute for Cancer Research, Victoria, Australia

4Johns Hopkins Medical Institutes, Baltimore, MD, USA

Soft Tissue Sarcoma: New Paradigms in Care


Soft tissue sarcomas are genetically heterogeneous and include a broad spectrum of phenotypes. Since the mid-1980s, diagnostic and therapeutic advances have witnessed a considerable improvement in patient outcomes with regard to not only survival but also function and palliation. More recent improvements however have only been incremental.

We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the molecular pathology underlying sarcoma development, the development of strategies to diagnose, stage, and treat these conditions, and the evaluation of outcomes. We are particularly interested in articles describing the new imaging modalities such as PET and MR spectroscopy; investigatory imaging tools for characterizing cellular behavior and response to treatment; advances in molecular genetics and molecular diagnostics; critical reviews of current surgical approaches to treatment and what paradigm shifts may be required to improve patient outcomes; instruments to measure functional and patient satisfaction outcomes; modalities of radiation therapy with an emphasis on the barriers to improving current care and what strategies may be required to overcome this; and current concepts in chemotherapy and novel strategies designed around small molecules, SiRNA, stem cells, and viral and nonviral gene therapy. Potential topics include, but are not limited to:

  • Recent developments in positron emission tomography
  • Recent developments in magnetic resonance tomography
  • Advanced medical imaging for assessing cellular and molecular interactions
  • Amputation or limb salvage surgery—critically analyzing the indications
  • Modern concepts in surgical margins including the classification and application of surgical margins
  • Concepts in the management of retroperitoneal sarcoma with an emphasis on barriers and facilitators
  • The role of radiotherapy in pediatric sarcomas
  • The role of radiosensitisers in radiotherapy
  • Combination chemotherapy and radiotherapy in sarcomas—what more needs to be done?
  • Recent advances in drug delivery systems with regard to targeted therapy
  • Role of gene therapy and targeted therapy in sarcoma treatment
  • Patient outcomes—limitations and improvements required in current assessment tools
  • The place of molecular pathology of the staging of sarcoma. When, why, and why not?

Before submission authors should carefully read over the journal's Author Guidelines, which are located at Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at according to the following timetable:


  • Special Issue
  • - Volume 2012
  • - Article ID 439208
  • - Editorial

Soft Tissue Sarcoma: New Paradigms in Care

Peter Choong
  • Special Issue
  • - Volume 2012
  • - Article ID 717213
  • - Clinical Study

The Toronto Extremity Salvage Score in Unoperated Controls: An Age, Gender, and Country Comparison

Mark Clayer | Simon Doyle | ... | Robert Grimer
  • Special Issue
  • - Volume 2012
  • - Article ID 315190
  • - Research Article

Functional Reconstruction of Sarcoma Defects Utilising Innervated Free Flaps

Damien Grinsell | Claudia Di Bella | Peter F. M. Choong
  • Special Issue
  • - Volume 2012
  • - Article ID 171342
  • - Review Article

A Systematic Review of the Recent Quality of Life Studies in Adult Extremity Sarcoma Survivors

Melissa H. Tang | Donald J. W. Pan | ... | Peter F. M. Choong
  • Special Issue
  • - Volume 2012
  • - Article ID 594512
  • - Clinical Study

Prognostic Value of Microvessel Density in Tumor and Peritumoral Area as Evaluated by CD31 Protein Expression and Argyrophilic Nucleolar Organizer Region Count in Endothelial Cells in Uterine Leiomyosarcoma

Ashot Avdalyan | Igor Bobrov | ... | Alexander Lazarev
  • Special Issue
  • - Volume 2012
  • - Article ID 626094
  • - Review Article

Targeted Therapies in Sarcomas: Challenging the Challenge

Juan Martín Liberal | Laura Lagares-Tena | ... | Oscar M. Tirado
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