Sarcoma

Osteosarcoma: Lessons Learned and Future Avenues


Publishing date
23 Nov 2012
Status
Published
Submission deadline
06 Jul 2012

Lead Editor

1Tata Memorial Centre, Mumbai, India

2MD Anderson Cancer Centre, Houston, TX, USA

3St. Vincent's Hospital, Melbourne, Australia

4Leiden University Medical Center, Leiden, The Netherlands


Osteosarcoma: Lessons Learned and Future Avenues

Description

The discovery of several chemotherapeutic agents that are active in osteosarcoma has greatly improved the survival compared to the prechemotherapy era. Disease-free survival has escalated from < 20% prior to the introduction of effective chemotherapy to 55–75%. Yet, over the last few decades, we seem to have reached a plateau with respect to further improving the results. The introduction of newer biological agents appears to improve survival but is open to debate. The role of newer imaging modalities, the increasing use of limb salvage with innovative techniques, and closer margins in an attempt to enhance function are avenues that show promise. While these newer developments are exciting, there remain several unanswered questions, which continue to plague us and can be resolved only with increasing data and multi-institutional collaborations. Methotrexate, among the first agents introduced for the treatment of this tumor, has been subjected to intense controversy and scrutiny but appears (finally) to have gained acceptance after 40 years, or has not it? Is it truly mandatory for treatment? Is chemotherapy alteration in poor responders beneficial? What salvage chemotherapy in relapses, and so forth are some of these queries.

We invite researchers and clinicians from all disciplines to contribute original research articles as well as review articles that will shed light on these and other issues in an effort to better understand, treat, and enhance outcomes in osteosarcoma. Potential topics include, but are not limited to:

  • Epidemiology
  • Biology of osteosarcoma
  • Role of newer imaging modalities (for diagnosis, staging, and predicting response to chemotherapy)
  • New chemotherapeutic agents
  • Targeted tumor therapy, antitumor angiogenesis, and biotherapy
  • Surface osteosarcomas
  • Secondary osteosarcomas
  • Extraskeletal osteosarcomas
  • Osteosarcomas in the elderly
  • Surgery in osteosarcoma
  • Role of radiotherapy
  • Salvage therapy
  • Palliative care
  • Outcome assessment tools and quality of life evaluation

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/srcm/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2013
  • - Article ID 641687
  • - Editorial

Osteosarcoma: Lessons Learned and Future Avenues

Ajay Puri | Norman Jaffe | Hans Gelderblom
  • Special Issue
  • - Volume 2013
  • - Article ID 203531
  • - Review Article

Osteosarcoma: Evolution of Treatment Paradigms

Norman Jaffe | Ajay Puri | Hans Gelderblom
  • Special Issue
  • - Volume 2013
  • - Article ID 480713
  • - Research Article

Rapamycin Inhibits ALDH Activity, Resistance to Oxidative Stress, and Metastatic Potential in Murine Osteosarcoma Cells

Xiaodong Mu | Christian Isaac | ... | Kurt Weiss
  • Special Issue
  • - Volume 2013
  • - Article ID 147541
  • - Research Article

Dkk-3, a Secreted Wnt Antagonist, Suppresses Tumorigenic Potential and Pulmonary Metastasis in Osteosarcoma

Carol H. Lin | Yi Guo | ... | Bang H. Hoang
  • Special Issue
  • - Volume 2012
  • - Article ID 636405
  • - Clinical Study

Survival Trends and Long-Term Toxicity in Pediatric Patients with Osteosarcoma

Melanie M. Hagleitner | Eveline S. J. M. de Bont | D. Maroeska W. M. te Loo
  • Special Issue
  • - Volume 2012
  • - Article ID 425636
  • - Review Article

Discovery of Biomarkers for Osteosarcoma by Proteomics Approaches

Yoshiyuki Suehara | Daisuke Kubota | ... | Tadashi Kondo
  • Special Issue
  • - Volume 2012
  • - Article ID 937506
  • - Research Article

Genes Regulated in Metastatic Osteosarcoma: Evaluation by Microarray Analysis in Four Human and Two Mouse Cell Line Systems

Roman Muff | Ram Mohan Ram Kumar | ... | Bruno Fuchs
  • Special Issue
  • - Volume 2012
  • - Article ID 164803
  • - Research Article

β-Catenin Does Not Confer Tumorigenicity When Introduced into Partially Transformed Human Mesenchymal Stem Cells

Sajida Piperdi | Lukas Austin-Page | ... | Richard Gorlick
  • Special Issue
  • - Volume 2012
  • - Article ID 126906
  • - Research Article

Enhanced Growth Inhibition of Osteosarcoma by Cytotoxic Polymerized Liposomal Nanoparticles Targeting the Alcam Cell Surface Receptor

Noah Federman | Jason Chan | ... | Christopher T. Denny
  • Special Issue
  • - Volume 2012
  • - Article ID 764796
  • - Research Article

Low-Grade Central Osteosarcoma: A Difficult Condition to Diagnose

A. M. Malhas | V. P. Sumathi | ... | R. J. Grimer
Sarcoma
 Journal metrics
Acceptance rate56%
Submission to final decision93 days
Acceptance to publication40 days
CiteScore2.340
Impact Factor-
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