A Quantitative Structure-Activity Relationship and Molecular Modeling Study on a Series of Biaryl Imidazole Derivatives Acting as H⁺/K⁺-ATPase Inhibitors

Table 2

Some proposed compounds belonging to the series of Table 1 and their activities predicted from (1).

No.	R	X	GTCI	TPSA	I1	I2	log (1/IC50)
1		O	0.519	81.65	1	0	7.24
2		O	0.514	119.48	1	0	7.76
3		CH2	0.514	110.25	1	0	7.63
4		CH2	0.514	133.41	1	0	7.95
5		CH2	0.519	127.32	1	0	7.88
6		CH2	0.517	138.90	1	0	8.33
7		O	0.519	159.71	1	0	8.34
8		O	0.514	142.64	1	0	8.08
9		O	0.514	131.06	1	0	7.92
10		CH2	0.514	121.83	1	0	7.79