Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine
Figure 1
AMP-induced behavioral changes. Mice were administered intraperitoneally with 1.0 mg/kg d-AMP once a day for 21 days or a same volume of saline during the same period. The spatial working memory of mice was measured two days after the last injection and the locomotion five days. Data were expressed as means ± SEM. Comparisons were made between CNT and AMP groups. *. For open-field test, all 12 mice in the AMP group entered the peripheral units more often than the average of CNT group. For Y-maze test, of 12 subjects in the AMP group, two mice showed spontaneous alternations (68 and 71%) above the average of CNT group (66%).
