Abnormal Behaviors and Microstructural Changes in White Matter of Juvenile Mice Repeatedly Exposed to Amphetamine
Figure 3
AMP reduced the amounts of GST-pi and MBP proteins in the frontal cortex and hippocampus. After treating with d-AMP or a same volume of saline for 21 days and subjected to behavioral tests, mice were sacrificed, their brains were dissected, and tissue samples from specific brain regions were processed for Western blot analysis. The amounts of GST-pi and MBP proteins in the frontal cortex, hippocampus, and striatum were measured. (a) shows representative Western blot images and (b) and (c) consists of two bar charts illustrating the statistical analysis of the Western blot results. Data were expressed as means ± SEM. Comparisons were made between CNT and AMP groups. *; **. In the measurement of GST-pi protein, all 6 frontal cortex samples in the AMP group showed lower levels than the average of CNT group. In the measurement of MBP protein, all frontal cortex and hippocampus samples in the AMP group showed lower levels than the average of CNT group.
